SynthesisNeuroscience and biobehavioral reviews2017
Brain imaging genetics in ADHD and beyond - Mapping pathways from gene to disorder at different levels of complexity.
Synthesis in Neuroscience and biobehavioral reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Systematic review of mitochondrial genetic variation in attention-deficit/hyperactivity disorder.European child & adolescent psychiatry · 2024Pooled it
- Genetic Markers of ADHD-Related Variations in Intracranial Volume.The American journal of psychiatry · 2019Pooled it
- The norepinephrine transporter gene modulates functional brain activations in drug-naïve children with attention-deficit/hyperactivity disorder.European child & adolescent psychiatry · 2026Article
- Abnormal Association Between Neural Activity and Genetic Expressions of Impulsivity in Attention-Deficit/Hyperactivity Disorder: An Adolescent Brain Cognitive Development Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- The 7-Repeat (7R) Variant of theInternational journal of molecular sciences · 2025Article
- Deep adversarial learning identifies ADHD-specific associations between apoptotic genes and white matter microstructure in frontal-striatum-cerebellum circuit.Translational psychiatry · 2025Article
- The Multidimensional Dynamic Feedback Model: A Comprehensive Framework for Understanding and Managing Attention-Deficit/Hyperactivity Disorder.Children (Basel, Switzerland) · 2025Review
- Combining transcranial direct current stimulation with music therapy improves cognitive function in schizophrenia: study protocol for a randomized, double-blind, sham-controlled clinical trial.Frontiers in psychiatry · 2025Article
- A multi-omics study of brain tissue transcription and DNA methylation revealing the genetic pathogenesis of ADHD.Briefings in bioinformatics · 2024Article
- Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology.Neurotoxicology · 2024Review
- A Qualitative Analysis of Perspectives on Self-directed Violence in a Prospective Longitudinal Study of Young Women With and Without Childhood ADHD.Journal of attention disorders · 2024Article
- The Relationship Between Emotion Dysregulation and Error Monitoring in Adolescents with ADHD.Research on child and adolescent psychopathology · 2024Article
- Shared genetic etiology between ADHD, task-related behavioral measures and brain activation during response inhibition in a youth ADHD case-control study.European archives of psychiatry and clinical neuroscience · 2024Article
- Annual Research Review: Perspectives on progress in ADHD science - from characterization to cause.Journal of child psychology and psychiatry, and allied disciplines · 2023Review
- ATP9A deficiency causes ADHD and aberrant endosomal recycling via modulating RAB5 and RAB11 activity.Molecular psychiatry · 2023Article
- Genomic patterns linked to gray matter alterations underlying working memory deficits in adults and adolescents with attention-deficit/hyperactivity disorder.Translational psychiatry · 2023Article
- Editorial: Modern statistical learning strategies in imaging genetics, volume II.Frontiers in neuroscience · 2023Article
- Attention-deficit hyperactivity disorder symptoms and brain morphology: Examining confounding bias.eLife · 2022Article
- Association between CLOCK gene polymorphisms and ADHD in Mexican teenagers: A comprehensive assessment.Psychiatry research · 2022Article
- Multivariate Genetic Structure of Externalizing Behavior and Structural Brain Development in a Longitudinal Adolescent Twin Sample.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Attention-deficit/hyperactivity disorder (ADHD) is a common and often persistent neurodevelopmental disorder. Beyond gene-finding, neurobiological parameters, such as brain structure, connectivity, and function, have been used to link genetic variation to ADHD symptomatology. We performed a systematic review of brain imaging genetics studies involving 62 ADHD candidate genes in childhood and adult ADHD cohorts. Fifty-one eligible research articles described studies of 13 ADHD candidate genes. Almost exclusively, single genetic variants were studied, mostly focussing on dopamine-related genes. While promising results have been reported, imaging genetics studies are thus far hampered by methodological differences in study design and analysis methodology, as well as limited sample sizes. Beyond reviewing imaging genetics studies, we also discuss the need for complementary approaches at multiple levels of biological complexity and emphasize the importance of combining and integrating findings across levels for a better understanding of biological pathways from gene to disease. These may include multi-modal imaging genetics studies, bioinformatic analyses, and functional analyses of cell and animal models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.