ArticleSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2017
Blunting of adaptive thermogenesis as a potential additional mechanism to promote weight loss after gastric bypass.
Article in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Evolution of the basal metabolic rate after Roux-en-Y gastric bypass: a systematic review and meta-analysis.Updates in surgery · 2023Pooled it
- Adaptive thermogenesis, at the level of resting energy expenditure, after diet alone or diet plus bariatric surgery.Obesity (Silver Spring, Md.) · 2024Trial
- Effects of a 4-month active weight loss phase followed by weight loss maintenance on adaptive thermogenesis in resting energy expenditure in former elite athletes.European journal of nutrition · 2022Trial
- Adaptive thermogenesis after moderate weight loss: magnitude and methodological issues.European journal of nutrition · 2022Trial
- Post-operative Metabolic Adaptation and its Influence on Long-Term Recurrent Weight Gain After Metabolic and Bariatric Surgery.Obesity surgery · 2026Article
- Angiotensin in the Arcuate: Mechanisms Integrating Cardiometabolic Control: The 2022 COH Mid-Career Award for Research Excellence.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Metabolic adaptation following gastric bypass surgery: results from a 2-year observational study.International journal of obesity (2005) · 2024Observational
- Stronger control of eating 3 months after sleeve gastrectomy predicts successful weight loss outcomes at one year.Obesity pillars · 2024Article
- Revisiting Resting Metabolic Rate: What is the Relation to Weight Fluctuations?Current obesity reports · 2023Review
- DNA methylation is differentially associated with glycemic outcomes by different types of weight-loss interventions: an epigenome-wide association study.Clinical epigenetics · 2023Article
- Recent Advances in Hypertension: Intersection of Metabolic and Blood Pressure Regulatory Circuits in the Central Nervous System.Hypertension (Dallas, Tex. : 1979) · 2021Review
- Relationship of Body Composition Measures and Metabolic Basal Rate with Gastrointestinal Hormones in Weight Regain 5 Years After Gastric Bypass.Obesity surgery · 2020Article
- Weight Recidivism After Roux-en-Y Gastric Bypass Surgery: An 11-Year Experience in a Multiethnic Medical Center.Obesity (Silver Spring, Md.) · 2019Article
- Postprandial Uridine Physiology Is Altered by Obesity.Gastroenterology · 2018Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAdaptive thermogenesis (AT) is described as a change in resting metabolic rate (RMR) that is greater than would be predicted from changes in lean body mass (LBM) and fat mass (FM) alone during periods of energy imbalance. Whereas an AT-related downregulation of RMR has been implicated in suboptimal weight loss and weight regain after nonsurgical weight loss, defense against AT may underpin the durable weight loss after laparoscopic Roux-en-Y gastric bypass (LRYGB) and other bariatric surgeries. However, methodological differences across the few studies that have evaluated postoperative AT limit interpretation as to the effects of these procedures on RMR.
objectiveTo quantify AT 6 months after LRYGB and laparoscopic adjustable gastric banding (LAGB).
settingThe study was conducted in a large university hospital in the United States.
methodsChanges in body composition and RMR were assessed in 13 severely obese adults 6 months after LRYGB (n = 8) and LAGB (n = 5). AT was calculated as the difference between measured RMR and RMR predicted from LBM, FM, age, and sex before and after surgery.
resultsRMR significantly decreased after LRYGB (-270±96 kcal/d, P<.01) but not after LAGB. Despite significantly greater reductions in weight, FM, and LBM with LRYGB than LAGB, AT responses after LRYGB (15±110 kcal/d, P = .7) and LAGB (42±97 kcal/d, P = .4) were similar (P = .7).
conclusionDespite significant weight and body composition changes, AT was minimal after LRYGB. A blunting of AT may be an additional mechanism that favors sustainable weight loss with LRYGB.
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Registered trials
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