ArticleBMC geriatrics2017
Higher skeletal muscle mass may protect against ischemic stroke in community-dwelling adults without stroke and dementia: The PRESENT project.
Article in BMC geriatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Hormone replacement therapy and muscle loss: repeated measures analysis from the Baltimore Longitudinal Study of Aging using DXA.Skeletal radiology · 2026Article
- Effect of abnormal distribution of abdominal adiposity and skeletal muscle on the outcomes of endovascular treatment for emergent large vessel occlusion.Journal of neurointerventional surgery · 2025Article
- Association between relative muscle strength and cardiometabolic multimorbidity in middle-aged and older Chinese adults.Acta diabetologica · 2025Article
- Mediating role of possible sarcopenia in the association between diabetes and stroke: finding from the China health and retirement longitudinal study.BMC geriatrics · 2025Article
- Sarcopenic Obesity Defined by Japanese Working Group on Sarcopenic Obesity in Post-Stroke Inpatients: Prevalence and Clinical Implications.Annals of geriatric medicine and research · 2025Article
- The effect of sarcopenia on prognosis in patients with mild acute ischemic stroke: a prospective cohort study.BMC neurology · 2025Article
- Sarcopenia as a Robust Predictor of Readmission within 6 Months among Individuals Experiencing Acute Stroke.Annals of geriatric medicine and research · 2024Article
- Appendicular lean mass and the risk of stroke and Alzheimer's disease: a mendelian randomization study.BMC geriatrics · 2024Article
- The causal relationship between sarcopenia-related traits and ischemic stroke: Insights from univariable and multivariable Mendelian randomization analyses.CNS neuroscience & therapeutics · 2024Article
- Effect of Dietary Habits on Alzheimer's Disease Progression.Yonsei medical journal · 2024Article
- Pathophysiological changes of muscle after ischemic stroke: a secondary consequence of stroke injury.Neural regeneration research · 2024Review
- Identifying shared diagnostic genes and mechanisms in vascular dementia and Alzheimer's disease via bioinformatics and machine learning.Journal of Alzheimer's disease reports · 2024Article
- Ischemic stroke and sarcopenia have an asymmetric bidirectional relationship based on a two-sample Mendelian randomization study.Frontiers in neurology · 2024Article
- Ischemic Stroke Induces Skeletal Muscle Damage and Alters Transcriptome Profile in Rats.Journal of clinical medicine · 2023Article
- A baseline sarcopenia index based on creatinine/cystatin C for the prediction of stroke recurrence and mortality in older survivors of first ischemic strokes.Frontiers in public health · 2023Article
- The Frequency of Daily Consumption of Sugar-Sweetened Beverages Is Associated with Reduced Muscle Mass Index in Adolescents.Nutrients · 2022Article
- Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging.International journal of molecular sciences · 2022Review
- Use of Facial Morphology to Determine Nutritional Status in Older Adults: Opportunities and Challenges.JMIR public health and surveillance · 2022Article
- Changes in predicted lean body mass, appendicular skeletal muscle mass, and body fat mass and cardiovascular disease.Journal of cachexia, sarcopenia and muscle · 2022Article
- Association between Preexisting Sarcopenia and Stroke in Patients with Type 2 Diabetes Mellitus.The journal of nutrition, health & aging · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is well known that a low skeletal muscle mass (SMM) is associated with stroke. However, it is unknown whether increasing muscle mass can prevent stroke.
methodsThis community-based cross-sectional study was supported by the regional government. SMM measurements and brain computed tomography was performed in 722 stroke-free and dementia-free subjects (aged 50-75 years). Subjects were divided into quartiles (Q) by SMM, checked using the bioelectrical impedance analysis method (InBody 770, InBody, Seoul, Korea). Odds ratios (ORs) of brain white matter changes/silent infarction (WMC/SI) were calculated. The subjects were then divided into two groups by sex and evaluated.
resultsIn the analysis of the four groups, the unadjusted ORs of Q2-Q4 were 0.616 (95% confidence interval [CI], 0.372-1.022; P = 0.061), 0.290 (CI, 0.159-0.530; P < 0.001), and 0.209 (CI, 0.108-0.403; P < 0.001) for the risk of WMC/SI. Adjusted ORs for age, hypertension, diabetes mellitus, education, hypercholesterolemia, and smoking were 0.994 (CI, 0.513-1.740; P = 0.085), 0.669 (CI, 0.329-1.362; P = 0.268), and 0.464 (CI, 0.219-0.984; P = 0.045). In the two-group (dichotomized) analysis, the unadjusted OR for the higher muscle mass groups (Q3 + Q4) was 0.313 (CI, 0.200-0.491; P < 0.001). The adjusted OR was 0.577 (CI, 0.340-0.979; P = 0.042). Considering sex, the adjusted OR were 0.351 (CI, 0.141-0.869; P = 0.024) in men and 0.771 (CI, 0.391-1.519; P = 0.452) in women.
conclusionsOur findings suggest that increased SMM may protect against WMC/SI, especially in men.
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