Trial reportBMC musculoskeletal disorders2017
Morphologic change of nerve and symptom relief are similar after mini-incision and endoscopic carpal tunnel release: a randomized trial.
Trial report in BMC musculoskeletal disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01972165 (Comparison of Subjective Outcomes and Changes of Ultrasonographic Morphology of Median Nerves of Mini-open and Endoscopic Carpal Tunnel Release in Patients With Idiopathic Carpal Tunnel Syndrome), which is not on this map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Subjective Outcomes and Changes of Ultrasonographic Morphology of Median Nerves of Mini-open and Endoscopic Carpal Tunnel Release in Patients With Idiopathic Carpal Tunnel Syndrome
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Comparative assessment of seven surgical procedures in Carpal Tunnel Syndrome: a network meta-analysis empowering physician-patient decision-making.Neurosurgical review · 2025Pooled it
- Diagnostic criteria and outcome measures in randomized clinical trials on carpal tunnel syndrome: a systematic review.Sao Paulo medical journal = Revista paulista de medicina · 2023Pooled it
- Open versus endoscopic carpal tunnel release: a systematic review and meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2020Pooled it
- Pooled it
- Sleep disturbance and response to surgical decompression in patients with carpal tunnel syndrome: a prospective randomized pilot comparison of open versus endoscopic release.Acta bio-medica : Atenei Parmensis · 2019Trial
- Reporting Quality of Randomized Controlled Trials in Elective Hand Surgery: A Systematic Review.Plastic and reconstructive surgery. Global open · 2025Article
- Comparing the Efficacy of Endoscopic Carpal Tunnel Repair Versus Open Surgery: A Systematic Review and Meta-analysis of Randomized Control Trials.Plastic and reconstructive surgery. Global open · 2025Article
- Endoscopic Versus Open Carpal Tunnel Release: A Systematic Review of Outcomes and Complications.Cureus · 2024Review
- Comparison of early clinical outcome in carpal tunnel release - mini-open technique with palmar incision vs. endoscopic technique with wrist crease incision.BMC musculoskeletal disorders · 2024Article
- Magnetic Resonance Imaging and Sonographic Features before and after Surgery in Carpal Tunnel Syndrome: Association with Clinical Findings.Clinics in orthopedic surgery · 2022Article
- A prospective cohort study: platelet-rich plasma combined with carpal tunnel release treating carpal tunnel syndrome.BMC musculoskeletal disorders · 2022Article
- Relationship Between Morphological Change of Median Nerve and Clinical Outcome Before and After Open Carpal Tunnel Release: Ultrasonographic 1-Year Follow-up After Operation.Hand (New York, N.Y.) · 2022Article
- Morphologic Analysis of the Carpal Tunnel and Median Nerve Following Open and Endoscopic Carpal Tunnel Release.Hand (New York, N.Y.) · 2021Article
- Carpal Tunnel Release Surgery- A Systematic Review of Open and Endoscopic Approaches.Anesthesiology and pain medicine · 2020Review
- Carpal Tunnel Syndrome Surgery: What You Should Know.Plastic and reconstructive surgery. Global open · 2020Review
- Comparison of two approaches for carpal tunnel release: Extended versus mini-open technique.Joint diseases and related surgery · 2020Article
- Sonographic follow-up after endoscopic carpal tunnel release for severe carpal tunnel syndrome: a one-year neuroanatomical prospective observational study.BMC musculoskeletal disorders · 2019Observational
- Ultrasonographic changes after steroid injection in carpal tunnel syndrome.Skeletal radiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe symptoms in carpal tunnel syndrome (CTS) can be ameliorated by open and endoscopic release of the transverse carpal ligament. It is unknown whether a mini-incision or endoscopic carpal tunnel release more effectively reverses the pathological changes that are observed in the median nerve in patients with CTS and these morphologic changes correlates with the subjective outcomes after carpal tunnel release. We hypothesized that (1) at 24 weeks after surgery, the subjective outcomes of mini-incision release and endoscopic release would not differ in patients with CTS; and (2) the ultrasonographic (US) morphology of the median nerve reverses similarly after mini-incision and endoscopic release; (3) the subjective outcomes correlates with these morphologic changes.
methodsBetween November 2011 and January 2013, 67 patients with CTS in their dominant wrist were randomized to either mini-incision (n = 32) or endoscopic (n = 35) release. Each patient was assessed by both the Boston Carpal Tunnel Questionnaire (BCTQ) and the Disabilities of the Arm, Shoulder, and Hand (DASH) pre-operatively and 24 weeks' post-operation. An US examination was conducted at both time points to measure the cross-sectional area (CSA) at the inlet, middle, and outlet (CSA-I, CSA-M and CSA-O) and the flattening ratio (FR) at the middle and outlet (FR-M and FR-O) of the median nerve.
resultsThe post-operative mean BCTQ and DASH scores were improved significantly from the pre-operative scores in both groups (p < 0.001). The mean CSA-I decreased and CSA-M and CSA-O increased similarly in both groups (by 3.3, 3.0, and 3.8 mm
conclusionsMini-incision and endoscopic release both similarly relieved subjective symptoms and functions along with the pathological changes in the median nerve morphology along the carpal tunnel in patients with idiopathic CTS. Symptom relief after surgical decompression seems to correlate with reduced nerve swelling at carpal inlet and reversed nerve flattening inside carpal tunnel.
trial registrationThis study was retrospectively registered in "ClinicalTrials.gov" at Oct 18th, 2013, and the registration number was NCT01972165 .
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.