ArticleBMC microbiology2017
High virulence sub-populations in Pseudomonas aeruginosa long-term cystic fibrosis airway infections.
Article in BMC microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Biofilm Formation ofMicroorganisms · 2025Review
- Harnessing hypoxia: bacterial adaptation and chronic infection in cystic fibrosis.FEMS microbiology reviews · 2025Review
- Pseudomonas aeruginosa faces a fitness trade-off between mucosal colonization and antibiotic tolerance during airway infection.Nature microbiology · 2024Article
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- Experimental evolution of yeast shows that public-goods upregulation can evolve despite challenges from exploitative non-producers.Nature communications · 2024Article
- Assessing the Potential ofACS pharmacology & translational science · 2024Article
- Genomic characterization of Pseudomonas spp. on food: implications for spoilage, antimicrobial resistance and human infection.BMC microbiology · 2024Article
- Co-occurring microflora and mucin driveISME communications · 2024Article
- The Effects of Antibiotic Combination Treatments on Pseudomonas aeruginosa Tolerance Evolution and Coexistence with Stenotrophomonas maltophilia.Microbiology spectrum · 2022Article
- Resistance Is Not Futile: The Role of Quorum Sensing Plasticity inMicroorganisms · 2022Review
- Periodically Disturbing the Spatial Structure of Biofilms Can Affect the Production of an Essential Virulence Factor inmSystems · 2021Article
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- How Bacterial Adaptation to Cystic Fibrosis Environment Shapes Interactions BetweenFrontiers in microbiology · 2021Review
- Novel Molecular Markers Linked toAntibiotics (Basel, Switzerland) · 2021Article
- Pseudomonas aeruginosa induces p38MAP kinase-dependent IL-6 and CXCL8 release from bronchial epithelial cells via a Syk kinase pathway.PloS one · 2021Article
- The three NADH dehydrogenases of Pseudomonas aeruginosa: Their roles in energy metabolism and links to virulence.PloS one · 2021Article
- NtrBC Selectively Regulates Host-Pathogen Interactions, Virulence, and Ciprofloxacin Susceptibility ofFrontiers in cellular and infection microbiology · 2021Article
- Epidemiology ofFrontiers in microbiology · 2020Article
- PQS Produced by the Pseudomonas aeruginosa Stress Response Repels Swarms Away from Bacteriophage and Antibiotics.Journal of bacteriology · 2019Article
- Transposable temperate phages promote the evolution of divergent social strategies inProceedings. Biological sciences · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPseudomonas aeruginosa typically displays loss of virulence-associated secretions over the course of chronic cystic fibrosis infections. This has led to the suggestion that virulence is a costly attribute in chronic infections. However, previous reports suggest that overproducing (OP) virulent pathotypes can coexist with non-producing mutants in the CF lung for many years. The consequences of such within-patient phenotypic diversity for the success of this pathogen are not fully understood. Here, we provide in-depth quantification of within-host variation in the production of three virulence associated secretions in the Liverpool cystic fibrosis epidemic strain of P. aeruginosa, and investgate the effect of this phenotypic variation on virulence in acute infections of an insect host model.
resultsWithin-patient variation was present for all three secretions (pyoverdine, pyocyanin and LasA protease). In two out of three patients sampled, OP isolates coexisted with under-producing mutants. In the third patient, all 39 isolates were under-producers of all three secretions relative to the transmissible ancestor LESB58. Finally, this phenotypic variation translated into variation in virulence in an insect host model.
conclusionsWithin population variation in the production of P. aeruginosa virulence-associated secretions can lead to high virulence sub-populations persisting in patients with chronic CF infections.
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