ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Development of a Rat Clinical Frailty Index.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- How human and animal frailty index studies can inform each other: a brief narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- High frailty index scores predict mortality and changes in blood-based biomarkers in aging female mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- A rabbit is not a mouse: a framework for the initial welfare assessment and long-term monitoring of genetically altered laboratory rabbits.Frontiers in veterinary science · 2026Article
- Analysis of the current state of frailty indexes and their implementation for aging intervention studies.Aging · 2025Review
- Evaluating frailty scores across experimental groups in rodent models: bridging physical and cognitive domains.FEBS open bio · 2025Article
- A review of frailty instruments in human medicine and proposal of a frailty instrument for dogs.Frontiers in veterinary science · 2023Review
- Spontaneous head twitches in aged rats: behavioral and molecular study.Psychopharmacology · 2022Article
- The Use of Dietary Supplements and Amino Acid Restriction Interventions to Reduce Frailty in Pre-Clinical Models.Nutrients · 2022Review
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- The relationship between social deprivation and a frailty index of cumulative deficits in French middle-aged caregivers.BMC geriatrics · 2022Article
- A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan.Frontiers in cardiovascular medicine · 2022Article
- Aging Induces Hepatic Oxidative Stress and Nuclear Proteomic Remodeling in Liver from Wistar Rats.Antioxidants (Basel, Switzerland) · 2021Article
- Late-life intermittent fasting decreases aging-related frailty and increases renal hydrogen sulfide production in a sexually dimorphic manner.GeroScience · 2021Article
- The degree of frailty as a translational measure of health in aging.Nature aging · 2021Review
- Sarcopenia and frailty in decompensated cirrhosis.Journal of hepatology · 2021Review
- Caloric Restriction May Help Delay the Onset of Frailty and Support Frailty Management.Frontiers in nutrition · 2021Review
- Hallmarks of frailty and osteosarcopenia in prematurely aged PolgAJournal of cachexia, sarcopenia and muscle · 2020Article
- Age, Sex and Overall Health, Measured As Frailty, Modify Myofilament Proteins in Hearts From Naturally Aging Mice.Scientific reports · 2020Article
- Allicin Reversed the Process of Frailty in Aging Male Fischer 344 Rats With Osteoporosis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Morphometric and Molecular Muscle Remodeling after Passive Stretching in Elderly Female Rats.Clinics (Sao Paulo, Brazil) · 2020Article
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Authors and funding
5 authors.
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Abstract
Rats are a commonly used model for aging studies, and a frailty assessment tool for rats would be of considerable value. There has been a recent focus on the development of preclinical models of frailty in mice. A mouse clinical frailty index (FI) was developed based on clinical frailty assessment tools. This FI measures the accumulation of clinically evident health-related deficits in mice. This paper aimed to develop a rat clinical FI. Male Fischer 344 rats were aged from 6 to 9 months (n = 12), and from 13 to 21 months (n = 41). A FI comprised of 27 health-related deficits was developed from a review of the literature and consultation with a veterinarian. Deficits were scored 0 if absent, 0.5 if mild, or 1 if severe. A FI score was determined for each rat every 3-4 months, and for the older group mortality was assessed up to 21 months. Mean FI scores significantly increased at each time point for the older rats. A high FI score measured at both 17 months of age and terminally was also associated with decreased probability of survival as assessed with Kaplan-Meier curves. The rat clinical FI has significant value for use in aging and interventional studies.
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