ArticlePloS one2017
Identifying radiation-induced survivorship syndromes affecting bowel health in a cohort of gynecological cancer survivors.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Return to Work Among Cancer Survivors With Treatment-induced Survivorship Syndromes
Dietary Fiber During Radiotherapy and Intestinal Inflammation - a Placebo-controlled Randomized Trial (FIDURA)
Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- TNFα signaling in radiation-induced chronic bowel dysfunction suggests therapeutic potential for IBD biologics.Molecular medicine (Cambridge, Mass.) · 2026Article
- Oat bran fiber protects against radiation-induced disruption of gut barrier dynamics and mucosal damage.NPJ biofilms and microbiomes · 2025Article
- Intra-abdominal Surgery and Intestinal Syndromes After Pelvic Radiation Therapy.Advances in radiation oncology · 2024Article
- A Systematic Review of Population-Based Studies of Chronic Bowel Symptoms in Cancer Survivors following Pelvic Radiotherapy.Cancers · 2023Review
- The physical and psychological aspects of quality of life mediates the effect of radiation-induced urgency syndrome on disability pension in gynecological cancer survivors.Cancer medicine · 2023Article
- Disability pension among gynaecological cancer survivors with or without radiation-induced survivorship syndromes.Journal of cancer survivorship : research and practice · 2022Article
- A Fiber-Rich Diet and Radiation-Induced Injury in the Murine Intestinal Mucosa.International journal of molecular sciences · 2021Article
- Observational
- Dose-response relationships of intestinal organs and excessive mucus discharge after gynaecological radiotherapy.PloS one · 2021Article
- A Preparatory Study for a Randomized Controlled Trial of Dietary Fiber Intake During Adult Pelvic Radiotherapy.Frontiers in nutrition · 2021Article
- Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation.Nutrients · 2020Article
- Long-term mucosal injury and repair in a murine model of pelvic radiotherapy.Scientific reports · 2019Article
- Lived experiences and quality of life after gynaecological cancer-An integrative review.Journal of clinical nursing · 2019Review
- Intake of citrus fruits and vegetables and the intensity of defecation urgency syndrome among gynecological cancer survivors.PloS one · 2019Observational
- Complex multimorbidity and health outcomes in older adult cancer survivors.Family medicine and community health · 2017Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundDuring radiotherapy unwanted radiation to normal tissue surrounding the tumor triggers survivorship diseases; we lack a nosology for radiation-induced survivorship diseases that decrease bowel health and we do not know which symptoms are related to which diseases.
methodsGynecological-cancer survivors were followed-up two to 15 years after having undergone radiotherapy; they reported in a postal questionnaire the frequency of 28 different symptoms related to bowel health. Population-based controls gave the same information. With a modified factor analysis, we determined the optimal number of factors, factor loadings for each symptom, factor-specific factor-loading cutoffs and factor scores.
resultsAltogether data from 623 survivors and 344 population-based controls were analyzed. Six factors best explain the correlation structure of the symptoms; for five of these a statistically significant difference (P< 0.001, Mann-Whitney U test) was found between survivors and controls concerning factor score quantiles. Taken together these five factors explain 42 percent of the variance of the symptoms. We interpreted these five factors as radiation-induced syndromes that may reflect distinct survivorship diseases. We obtained the following frequencies, defined as survivors having a factor loading above the 95 percent percentile of the controls, urgency syndrome (190 of 623, 30 percent), leakage syndrome (164 of 623, 26 percent), excessive gas discharge (93 of 623, 15 percent), excessive mucus discharge (102 of 623, 16 percent) and blood discharge (63 of 623, 10 percent).
conclusionLate effects of radiotherapy include five syndromes affecting bowel health; studying them and identifying the underlying survivorship diseases, instead of the approximately 30 long-term symptoms they produce, will simplify the search for prevention, alleviation and elimination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.