ArticlePLoS pathogens2017
Identification of cyst nematode B-type CLE peptides and modulation of the vascular stem cell pathway for feeding cell formation.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 91 citations in OpenAlex.
- From Sequential Gland Replacement to Recurrent Gland Coordination: A Comparative Framework for Subventral and Dorsal Oesophageal Gland Effectors Across Plant-Parasitic Nematode Lifestyles.Plants (Basel, Switzerland) · 2026Review
- Root-knot-nematode-derived mimics of RGF peptides hijack host signalling to orchestrate feeding site formation.Nature plants · 2026Article
- Plant cell surface receptors.The Plant journal : for cell and molecular biology · 2026Review
- Molecular mimicry and trafficking of peptide effectors in sedentary nematodes: emerging drivers of feeding site formation and host signaling hijack.Crop health · 2026Review
- Pathogen-Mediated Cell Fusion and Actin Cytoskeleton.Advances in experimental medicine and biology · 2026Review
- RNA tomography reveals spatial gene expression maps of Arabidopsis thaliana roots infected with Heterodera schachtii.The New phytologist · 2026Article
- Damage activates EXG1 and RLP44 to suppress vascular differentiation during regeneration in Arabidopsis.Plant communications · 2025Article
- Identification through a transcriptomic approach of candidate genes involved in the adaptation of the cyst nematode Globodera pallida to the potato resistance factor GpaVBMC genomics · 2025Article
- A major role of class III HD-ZIPs in promoting sugar beet cyst nematode parasitism in Arabidopsis.PLoS pathogens · 2024Article
- The origin, deployment, and evolution of a plant-parasitic nematode effectorome.PLoS pathogens · 2024Article
- CLAVATA signaling in plant-environment interactions.Plant physiology · 2024Review
- Functional studies of plant transcription factors and their relevance in the plant root-knot nematode interaction.Frontiers in plant science · 2024Review
- CLE peptide signaling in plant-microbe interactions.Frontiers in plant science · 2024Review
- Functional Modules in the Meristems: "Tinkering" in Action.Plants (Basel, Switzerland) · 2023Review
- Root-knot nematode modulates plant CLE3-CLV1 signaling as a long-distance signal for successful infection.Science advances · 2023Article
- Beet cyst nematode HsSNARE1 interacts with both AtSNAP2 and AtPR1 and promotes disease in Arabidopsis.Journal of advanced research · 2023Article
- Pathogen-triggered changes in plant development: Virulence strategies or host defense mechanism?Frontiers in microbiology · 2023Review
- Characterization and response of two potato receptor-like kinases to cyst nematode infection.Plant signaling & behavior · 2022Article
- A novel sugar beet cyst nematode effector 2D01 targets the Arabidopsis HAESA receptor-like kinase.Molecular plant pathology · 2022Article
- Spatial range, temporal span, and promiscuity of CLE-RLK signaling.Frontiers in plant science · 2022Review
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cell pools in the SAM (shoot apical meristem), RAM (root apical meristem) and vascular procambium/cambium are regulated by CLE-receptor kinase-WOX signaling modules. Previous data showed that cyst nematode CLE-like effector proteins delivered into host cells through a stylet, act as ligand mimics of plant A-type CLE peptides and are pivotal for successful parasitism. Here we report the identification of a new class of CLE peptides from cyst nematodes with functional similarity to the B-type CLE peptide TDIF (tracheary element differentiation inhibitory factor) encoded by the CLE41 and CLE44 genes in Arabidopsis. We further demonstrate that the TDIF-TDR (TDIF receptor)-WOX4 pathway, which promotes procambial meristem cell proliferation, is involved in beet cyst nematode Heterodera schachtii parasitism. We observed activation of the TDIF pathway in developing feeding sites, reduced nematode infection in cle41 and tdr-1 wox4-1 mutants, and compromised syncytium size in cle41, tdr-1, wox4-1 and tdr-1 wox4-1 mutants. By qRT-PCR and promoter:GUS analyses, we showed that the expression of WOX4 is decreased in a clv1-101 clv2-101 rpk2-5 mutant, suggesting that WOX4 is a potential downstream target of nematode CLEs. Exogenous treatment with both nematode A-type and B-type CLE peptides induced massive cell proliferation in wild type roots, suggesting that the two types of CLEs may regulate cell proliferation during feeding site formation. These findings highlight an important role of the procambial cell proliferation pathway in cyst nematode feeding site formation.
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