ArticlePloS one2017
Center or periphery? Modeling the effects of focal adhesion placement during cell spreading.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Review
- Anisotropy profoundly alters stress fields within contractile cells and cell aggregates.Biomechanics and modeling in mechanobiology · 2022Article
- Plasmonic Biosensing for Label-Free Detection of Two Hallmarks of Cancer Cells: Cell-Matrix Interaction and Cell Division.Biosensors · 2022Article
- Spatial and temporal dynamics of RhoA activities of single breast tumor cells in a 3D environment revealed by a machine learning-assisted FRET technique.Experimental cell research · 2022Article
- Analysis of Actin and Focal Adhesion Organisation in U2OS Cells on Polymer Nanostructures.Nanoscale research letters · 2021Article
- Cell Shape and Durotaxis Explained from Cell-Extracellular Matrix Forces and Focal Adhesion Dynamics.iScience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Focal adhesions are often observed at the cell's periphery. We provide an explanation for this observation using a system-level mathematical model of a cell interacting with a two-dimensional substrate. The model describes the biological cell as a hypoelastic continuum material whose behavior is coupled to a deformable, linear elastic substrate via focal adhesions that are represented by collections of linear elastic attachments between the cell and the substrate. The evolution of the focal adhesions is coupled to local intracellular stresses which arise from mechanical cell-substrate interactions. Using this model we show that the cell has at least three mechanisms through which it can control its intracellular stresses: focal adhesion position, size, and attachment strength. We also propose that one reason why focal adhesions are typically located on the cell periphery instead of its center is because peripheral focal adhesions allow the cell to be more sensitive to changes in the microenvironment. This increased sensitivity is caused by the fact that peripherally located focal adhesions allow the cells to modulate its intracellular properties over a much larger portion of the cell area.
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Registered trials
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