Evidence map›Paper›PMID 28157546›Full record

ArticleVirology2017

Respiratory syncytial virus infection induces a subset of types I and III interferons in human dendritic cells.

Philippa Hillyer, Viraj P Mane, Aaron Chen, Maria B Dos Santos, Lynnsie M Schramm, Rachel E Shepard, Cindy Luongo, Cyril Le Nouën, Lei Huang, Lihan Yan and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

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  20. Transient Depletion of CD169Frontiers in immunology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Philippa HillyerLaboratory of Immunobiochemistry, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Viraj P ManeLaboratory of Immunobiochemistry, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Aaron ChenLaboratory of Immunobiochemistry, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Maria B Dos SantosLaboratory of Immunobiochemistry, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Lynnsie M SchrammLaboratory of Immunobiochemistry, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Rachel E ShepardLaboratory of Immunobiochemistry, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Cindy LuongoLaboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes for Health, Bethesda, MD, United States.
Cyril Le NouënLaboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes for Health, Bethesda, MD, United States.
Lei HuangOffice of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Lihan YanOffice of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Ursula J BuchholzLaboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes for Health, Bethesda, MD, United States.
Ronald G JubinPBL Interferon Source, Piscataway, NJ, United States.
Peter L CollinsLaboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes for Health, Bethesda, MD, United States.
Ronald L RabinLaboratory of Immunobiochemistry, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States. Electronic address: ronald.rabin@fda.hhs.gov.
Center for Biologics Evaluation and Research · USNational Institute of Allergy and Infectious Diseases · US

Funding

Laboratory Studies of Human Respiratory Syncytial Virus and Other PneumovirusesZIAAI000372 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BUCHHOLZ, URSULA · 2009 to 2025
$21.8M
Intramural FDA HHS FD999999
6 · The paper itself

Abstract

Whether respiratory syncytial virus (RSV) induces severe infantile pulmonary disease may depend on viral strain and expression of types I and III interferons (IFNs). These IFNs impact disease severity by inducing expression of many anti-viral IFN-stimulated genes (ISGs). To investigate the impact of RSV strain on IFN and ISG expression, we stimulated human monocyte-derived DCs (MDDCs) with either RSV A2 or Line 19 and measured expression of types I and III IFNs and ISGs. At 24h, A2 elicited higher ISG expression than Line 19. Both strains induced MDDCs to express genes for IFN-β, IFN-α1, IFN-α8, and IFN-λ1-3, but only A2 induced IFN-α2, -α14 and -α21. We then show that IFN-α8 and IFN-α14 most potently induced MDDCs and bronchial epithelial cells (BECs) to express ISGs. Our findings demonstrate that RSV strain may impact patterns of types I and III IFN expression and the magnitude of the ISG response by DCs and BECs.

Indexed as

AdultBronchiCells, CulturedCytokinesDendritic CellsEpithelial CellsHumansInflammationInterferon-alphaInterferon-betaLungRespiratory MucosaRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsCytokinesInterferon-alphaInterferon-betaBronchial epithelial cellDendritic cellInnate immunityInterferonInterferon stimulated geneInterferon subtypeRespiratory syncytial virus

Identifiers

PMID28157546
PMCPMC5337151
OpenAlexW2584755454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.