ArticleJournal of psychiatric research2017
A comparison of structural connectivity in anxious depression versus non-anxious depression.
Article in Journal of psychiatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Cerebral diffusion kurtosis imaging to assess the pathophysiology of postpartum depression.Scientific reports · 2020Trial
- Anxious depression as a clinically relevant subtype of pediatric major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2019Trial
- Cortical thickness is not associated with current depression in a clinical treatment study.Human brain mapping · 2017Trial
- Network-based analysis of differential white matter connectivity in major depressive disorder with and without comorbid anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Different activation in left dorsolateral prefrontal cortex and left orbitofrontal cortex during autobiographical memory tasks is associated with depressive disorder with different levels of resilience: a functional near-infrared spectroscopy study.Frontiers in psychology · 2025Article
- The Effects of Variation in the GABANeuropsychiatric disease and treatment · 2024Article
- Sex differences in patterns of white matter neuroplasticity after balance training in young adults.Frontiers in human neuroscience · 2024Article
- Review
- An examination of the reliability of seed-to-seed resting state functional connectivity in tinnitus patients.Neuroimage. Reports · 2023Article
- Differential Tractography and Correlation Tractography Findings on Patients With Mild Traumatic Brain Injury: A Pilot Study.Frontiers in human neuroscience · 2022Article
- Common and Specific Alterations of Amygdala Subregions in Major Depressive Disorder With and Without Anxiety: A Combined Structural and Resting-State Functional MRI Study.Frontiers in human neuroscience · 2021Article
- Chronic disorders of consciousness: a case report with longitudinal evaluation of disease progression using 7 T magnetic resonance imaging.BMC neurology · 2020Article
- Disrupted Structural Brain Network Organization Behind Depressive Symptoms in Major Depressive Disorder.Frontiers in psychiatry · 2020Article
- White matter abnormalities in depression: A categorical and phenotypic diffusion MRI study.NeuroImage. Clinical · 2019Article
- Altered Topology of the Structural Brain Network in Patients With Post-stroke Depression.Frontiers in neuroscience · 2019Article
- Association of deposition of tau and amyloid-β proteins with structural connectivity changes in cognitively normal older adults and Alzheimer's disease spectrum patients.Brain and behavior · 2018Article
- Statistical harmonization corrects site effects in functional connectivity measurements from multi-site fMRI data.Human brain mapping · 2018Article
- Development and evaluation of a multimodal marker of major depressive disorder.Human brain mapping · 2018Article
- Failure to Replicate the Association Between Fractional Anisotropy and the Serotonin Transporter Gene (5-HTTLPR, rs25531).Frontiers in behavioral neuroscience · 2018Article
- Abnormal white matter integrity in Chinese young adults with first-episode medication-free anxious depression: a possible neurological biomarker of subtype major depressive disorder.Neuropsychiatric disease and treatment · 2018Article
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundMajor depressive disorder (MDD) and anxiety disorders are highly co-morbid. Research has shown conflicting evidence for white matter alteration and amygdala volume reduction in mood and anxiety disorders. To date, no studies have examined differences in structural connectivity between anxious depressed and non-anxious depressed individuals. This study compared fractional anisotropy (FA) and density of selected white matter tracts and amygdala volume between anxious depressed and non-anxious depressed individuals.
methods64- direction DTI and T1 scans were collected from 110 unmedicated subjects with MDD, 39 of whom had a co-morbid anxiety disorder diagnosis. Region of interest (ROI) and tractography methods were performed to calculate amygdala volume and FA in the uncinate fasciculus, respectively. Diffusion connectometry was performed to identify whole brain group differences in white matter health. Correlations were computed between biological and clinical measures.
resultsTractography and ROI analyses showed no significant differences between bilateral FA values or bilateral amygdala volumes when comparing the anxious depressed and non-anxious depressed groups. The diffusion connectometry analysis showed no significant differences in anisotropy between the groups. Furthermore, there were no significant relationships between MRI-based and clinical measures.
conclusionThe lack of group differences could indicate that structural connectivity and amygdalae volumes of those with anxious-depression are not significantly altered by a co-morbid anxiety disorder. Improving understanding of anxiety co-morbid with MDD would facilitate development of treatments that more accurately target the underlying networks.
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