ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2017
Is IPT more effective in high-burden settings? Modelling the effect of tuberculosis incidence on IPT impact.
Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
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- A social network analysis model approach to understand tuberculosis transmission in remote rural Madagascar.BMC public health · 2023Article
- Variance-based sensitivity analysis of tuberculosis transmission models.Journal of the Royal Society, Interface · 2022Article
- Estimating the long-term effects of mass screening for latent and active tuberculosis in the Marshall Islands.International journal of epidemiology · 2022Article
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- Factors associated with antiretroviral therapy adherence among adolescents living with HIV in the era of isoniazid preventive therapy as part of HIV care.PLOS global public health · 2022Article
- Effectiveness of isoniazid preventive therapy on incidence of tuberculosis among HIV-infected adults in programme setting.The Indian journal of medical research · 2020Article
- The predicted impact of tuberculosis preventive therapy: the importance of disease progression assumptions.BMC infectious diseases · 2020Article
- Strategic investment in tuberculosis control in the Republic of Bulgaria.Epidemiology and infection · 2019Article
- Decreased risk of HIV-associated TB during antiretroviral therapy expansion in rural Eswatini from 2009 to 2016: a cohort and population-based analysis.Tropical medicine & international health : TM & IH · 2019Article
- Projected population-wide impact of antiretroviral therapy-linked isoniazid preventive therapy in a high-burden setting.AIDS (London, England) · 2019Article
- Tracking the rate of initiation and retention on isoniazid preventive therapy in a high human immunodeficiency virus and tuberculosis burden setting of Lesotho.Southern African journal of infectious diseases · 2019Article
- Tuberculosis Elimination in the Asia-Pacific Region and the WHO Ethics Guidance.Tropical medicine and infectious disease · 2018Article
- Monitoring tuberculosis contact tracing outcomes in Western Sydney, Australia.BMJ open respiratory research · 2018Article
- Modelling heterogeneity in host susceptibility to tuberculosis and its effect on public health interventions.PloS one · 2018Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
settingIsoniazid preventive therapy (IPT) is effective for preventing active tuberculosis (TB), although its mechanism of action is poorly understood and the optimal disease burden for IPT use has not been defined.
objectiveTo describe the relationship between TB incidence and IPT effectiveness.
methodsWe constructed a model of TB transmission dynamics to investigate IPT effectiveness under various epidemiological settings. The model structure was intended to be highly adaptable to uncertainty in both input parameters and the mechanism of action of IPT. To determine the optimal setting for IPT use, we identified the lowest number needed to treat (NNT) with IPT to prevent one case of active TB.
resultsWe found that the NNT as a function of TB incidence shows a 'U-shape', whereby IPT impact is greatest at an intermediate incidence and attenuated at both lower and higher incidence levels. This U-shape was observed over a broad range of parameter values; the optimal TB incidence was between 500 and 900 cases per 100 000 per year.
conclusionsTB burden is a critical factor to consider when making decisions about communitywide implementation of IPT. We believe that the total disease burden should not preclude programmatic application of IPT.
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