ArticleJournal of biomedical optics2017
Theoretical model for optical oximetry at the capillary level: exploring hemoglobin oxygen saturation through backscattering of single red blood cells.
Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
- Cell membrane-encased thylakoid as white light triggered PDT therapy for facile and targeted choroidal melanoma treatment.Bioactive materials · 2026Article
- Depth-gated Fourier transform to accelerate spectral recovery in visible light optical coherence tomography retinal oximetry.Optics letters · 2025Article
- Correlation Between Retinal Vascular Oxygen Saturation, Red Blood Cell Parameters and Hemorheology Parameters in Healthy Adults.Clinical optometry · 2025Article
- Biochemical hallmarks-targeting antineoplastic nanotherapeutics.Bioactive materials · 2024Review
- Red blood cell-derived materials for cancer therapy: Construction, distribution, and applications.Materials today. Bio · 2024Review
- Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry.Communications medicine · 2023Article
- Assessment of internal refractive index profile of stochastically inhomogeneous nuclear models via analysis of two-dimensional optical scattering patterns.Journal of biomedical optics · 2021Article
- Retinal capillary oximetry with visible light optical coherence tomography.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Ocular anterior chamber blood cell population differentiation using spectroscopic optical coherence tomography.Biomedical optics express · 2019Article
- Refractive index of human red blood cells between 290 nm and 1100 nm determined by optical extinction measurements.Scientific reports · 2019Article
- Quantitative quality-control metrics forBiomedical optics express · 2019Article
- Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging.Light, science & applications · 2019Article
- Deep spectral learning for label-free optical imaging oximetry with uncertainty quantification.Light, science & applications · 2019Article
- Rodent retinal circulation organization and oxygen metabolism revealed by visible-light optical coherence tomography.Biomedical optics express · 2018Article
- Fiber-based visible and near infrared optical coherence tomography (vnOCT) enables quantitative elastic light scattering spectroscopy in human retina.Biomedical optics express · 2018Article
- Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography.Light, science & applications · 2018Article
- Visible-light optical coherence tomography: a review.Journal of biomedical optics · 2017Review
- The path to clinical translation for visible light optical coherence tomography in retinal imaging.Taiwan journal of ophthalmologyReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Oxygen saturation ( sO 2 ) of red blood cells (RBCs) in capillaries can indirectly assess local tissue oxygenation and metabolic function. For example, the altered retinal oxygenation in diabetic retinopathy and local hypoxia during tumor development in cancer are reflected by abnormal sO 2 of local capillary networks. However, it is far from clear whether accurate label-free optical oximetry (i.e., measuring hemoglobin sO 2 ) is feasible from dispersed RBCs at the single capillary level. The sO 2 -dependent hemoglobin absorption contrast present in optical scattering signal is complicated by geometry-dependent scattering from RBCs. We present a numerical study of backscattering spectra from single RBCs based on the first-order Born approximation, considering practical factors: RBC orientations, size variation, and deformations. We show that the oscillatory spectral behavior of RBC geometries is smoothed by variations in cell size and orientation, resulting in clear sO 2 -dependent spectral contrast. In addition, this spectral contrast persists with different mean cellular hemoglobin content and different deformations of RBCs. This study shows for the first time the feasibility of, and provides a theoretical model for, label-free optical oximetry at the single capillary level using backscattering-based imaging modalities, challenging the popular view that such measurements are impossible at the single capillary level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.