ArticleScientific reports2017
Age, but not anthelmintic treatment, is associated with urinary neopterin levels in semi-free ranging Barbary macaques.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Minimal Evidence of Inflammaging in Naturalistic Chimpanzee Populations.American journal of biological anthropology · 2026Article
- Taxonomic variation in immune response strategies among primates.Genes and immunity · 2025Review
- Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild.American journal of primatology · 2025Review
- Comparison of age-related inflammation and oxidative stress in two lemur species.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Neopterin extendsmicroPublication biology · 2025Article
- High temperatures are associated with decreased immune system performance in a wild primate.Science advances · 2024Article
- Neopterin Levels in Bonobos Vary Seasonally and Reflect Symptomatic Respiratory Infections.EcoHealth · 2023Article
- Urinary neopterin reflects immunological variation associated with age, helminth parasitism, and the microbiome in a wild primate.Scientific reports · 2022Article
- Validating Urinary Neopterin as a Biomarker of Immune Response in Captive and Wild Capuchin Monkeys.Frontiers in veterinary science · 2022Article
- Urinary neopterin of wild chimpanzees indicates that cell-mediated immune activity varies by age, sex, and female reproductive status.Scientific reports · 2021Article
- Ecological, parasitological and individual determinants of plasma neopterin levels in a natural mandrill population.International journal for parasitology. Parasites and wildlife · 2020Article
- Urinary suPAR: a non-invasive biomarker of infection and tissue inflammation for use in studies of large free-ranging mammals.Royal Society open science · 2020Article
- Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees.PloS one · 2020Article
- Urinary neopterin levels increase and predict survival during a respiratory outbreak in wild chimpanzees (Taï National Park, Côte d'Ivoire).Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studying host parasite interactions and their implications for evolution and ecology recently received increasing attention, particularly with regard to host physiology and immunity. Here we assess variation of urinary neopterin (uNEO), a marker of cellular immune activation and iummunosenescence, in response to age and anthelmintic treatment in semi-free ranging Barbary macaques (Macaca sylvanus). Urinary NEO levels were measured via enzyme-immunoassay from 179 urine samples of 43 individuals between 5-29 years of age. Efficiency of treatment was assessed by Mc Master flotation on repeated faecal samples, including 18 untreated individuals as control group. We used linear mixed models with age and parasite status as main effects, controlling for sex and physical condition, assessed through urinary C-Peptide-levels, with social group and ID as random factors. Urinary NEO levels significantly increased with age, suggesting that changes in aging Barbary macaque immune responses are consistent with immunosenescence described in human and nonhuman primates and can be detected via uNEO measurements. Anthelmintic treatment, however, had no influence on uNEO levels, potentially due to quick reinfections or attenuated immune responses in repeated infections. We conclude that uNEO is a potential non-invasive marker for immune function and particularly immunosenescence in wildlife.
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