ArticleScientific reports2017
Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Protocol for repeated Plasmodium chabaudi infection in a murine malaria model.STAR protocols · 2026Article
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- Differential Response and Recovery Dynamics of HSPC Populations FollowingInternational journal of molecular sciences · 2025Article
- Cellular iron governs the host response to malaria.PLoS pathogens · 2023Article
- Friend virus severity is associated with male mouse social status and environmental temperature.Animal behaviour · 2022Article
- Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria.eLife · 2022Article
- Experimental Models to Study the Pathogenesis of Malaria-Associated Acute Respiratory Distress Syndrome.Frontiers in cellular and infection microbiology · 2022Review
- Neutrophils in malaria: A double-edged sword role.Frontiers in immunology · 2022Review
- Differential Trafficking and Expression of PIR Proteins in Acute and ChronicFrontiers in cellular and infection microbiology · 2022Article
- Brain-wide functional architecture remodeling by alcohol dependence and abstinence.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Comparison of whole blood and spleen transcriptional signatures over the course of an experimental malaria infection.Scientific reports · 2019Article
- Neutrophil extracellular traps drive inflammatory pathogenesis in malaria.Science immunology · 2019Article
- Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.Nature communications · 2019Article
- A fast and cost-effective microsampling protocol incorporating reduced animal usage for time-series transcriptomics in rodent malaria parasites.Malaria journal · 2019Article
- Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome.Journal of immunology research · 2019Article
- Systems Biology-Based Investigation of Host-Plasmodium Interactions.Trends in parasitology · 2018Review
- Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions.Microbiology and molecular biology reviews : MMBR · 2018Review
- Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion.Malaria journal · 2018Article
- Neutrophils and Malaria.Frontiers in immunology · 2018Review
- Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern.Wellcome open research · 2018Article
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
The influence of parasite genetic factors on immune responses and development of severe pathology of malaria is largely unknown. In this study, we performed genome-wide transcriptomic profiling of mouse whole blood during blood-stage infections of two strains of the rodent malaria parasite Plasmodium chabaudi that differ in virulence. We identified several transcriptomic signatures associated with the virulent infection, including signatures for platelet aggregation, stronger and prolonged anemia and lung inflammation. The first two signatures were detected prior to pathology. The anemia signature indicated deregulation of host erythropoiesis, and the lung inflammation signature was linked to increased neutrophil infiltration, more cell death and greater parasite sequestration in the lungs. This comparative whole-blood transcriptomics profiling of virulent and avirulent malaria shows the validity of this approach to inform severity of the infection and provide insight into pathogenic mechanisms.
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