ArticleScientific reports2017
Epigenetic origin of evolutionary novel centromeres.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- Optimized Genome-Wide Profiling of Centromeric Chromatin Complexes by ChIP-seq.Current protocols · 2026Article
- Unconventional centromere architectures in Tapirus indicus reveal hotspots for satellite-free centromere formation in Perissodactyla.Communications biology · 2026Article
- Telomere-to-telomere genome assembly of Oryza australiensis reveals transposon-driven centromere repositioning and shared EE-DD ancestry.Nature communications · 2026Article
- A segmental duplication-mediated deletion leads to neocentromere formation in orangutans.bioRxiv : the preprint server for biology · 2026Article
- CENP-A and centromere evolution in equids.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025Review
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- Review
- Pan-centromere reveals widespread centromere repositioning of soybean genomes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Human centromere repositioning activates transcription and opens chromatin fibre structure.Nature communications · 2022Article
- Molecular Dynamics and Evolution of Centromeres in the Genus Equus.International journal of molecular sciences · 2022Review
- Induction of spontaneous human neocentromere formation and long-term maturation.The Journal of cell biology · 2021Article
- BL1391: an established cell line from a human malignant peripheral nerve sheath tumor with unique genomic features.Human cell · 2021Article
- Rapid Birth or Death of Centromeres on Fragmented Chromosomes in Maize.The Plant cell · 2020Article
- Centromere deletion ineLife · 2020Article
- Eight million years of maintained heterozygosity in chromosome homologs of cercopithecine monkeys.Chromosoma · 2020Article
- Genome Evolution in Arabideae Was Marked by Frequent Centromere Repositioning.The Plant cell · 2020Article
- Centromere repositioning causes inversion of meiosis and generates a reproductive barrier.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
Abstract
Most evolutionary new centromeres (ENC) are composed of large arrays of satellite DNA and surrounded by segmental duplications. However, the hypothesis is that ENCs are seeded in an anonymous sequence and only over time have acquired the complexity of "normal" centromeres. Up to now evidence to test this hypothesis was lacking. We recently discovered that the well-known polymorphism of orangutan chromosome 12 was due to the presence of an ENC. We sequenced the genome of an orangutan homozygous for the ENC, and we focused our analysis on the comparison of the ENC domain with respect to its wild type counterpart. No significant variations were found. This finding is the first clear evidence that ENC seedings are epigenetic in nature. The compaction of the ENC domain was found significantly higher than the corresponding WT region and, interestingly, the expression of the only gene embedded in the region was significantly repressed.
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