ArticleNature communications2017
Evolution of Shh endoderm enhancers during morphological transition from ventral lungs to dorsal gas bladder.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function.Genes & development · 2025Article
- The Homeobox Transcription Factor CUX1 Coordinates Postnatal Epithelial Developmental Timing but Is Dispensable for Lung Organogenesis and Regeneration.American journal of respiratory cell and molecular biology · 2025Article
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- Canonical Wnt signaling is not required forFrontiers in physiology · 2023Article
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- Tbx5 driveseLife · 2021Article
- Complete lung agenesis caused by complex genomic rearrangements with neo-TAD formation at the SHH locus.Human genetics · 2021Article
- Inference of the ancestral vertebrate phenotype through vestiges of the whole-genome duplications.Briefings in functional genomics · 2018Review
- A staging table for the embryonic development of the brownbanded bamboo shark (Chiloscyllium punctatum).Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Enhancer adoption caused by genomic insertion elicits interdigitalProceedings of the National Academy of Sciences of the United States of America · 2018Article
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- Problems in Fish-to-Tetrapod Transition: Genetic Expeditions Into Old Specimens.Frontiers in cell and developmental biology · 2018Review
- SHH signaling directed by two oral epithelium-specific enhancers controls tooth and oral development.Scientific reports · 2017Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shh signalling plays a crucial role for endoderm development. A Shh endoderm enhancer, MACS1, is well conserved across terrestrial animals with lungs. Here, we first show that eliminating mouse MACS1 causes severe defects in laryngeal development, indicating that MACS1-directed Shh signalling is indispensable for respiratory organogenesis. Extensive phylogenetic analyses revealed that MACS1 emerged prior to the divergence of cartilaginous and bony fishes, and even euteleost fishes have a MACS1 orthologue. Meanwhile, ray-finned fishes evolved a novel conserved non-coding sequence in the neighbouring region. Transgenic assays showed that MACS1 drives reporter expression ventrally in laryngeal epithelium. This activity has been lost in the euteleost lineage, and instead, the conserved non-coding sequence of euteleosts acquired an enhancer activity to elicit dorsal epithelial expression in the posterior pharynx and oesophagus. These results implicate that evolution of these two enhancers is relevant to the morphological transition from ventral lungs to dorsal gas bladder.
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