ArticleBiomedical engineering online2016
Re-examination of the mechanical anisotropy of porcine thoracic aorta by uniaxial tensile tests.
Article in Biomedical engineering online, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Biaxial Mechanical Behavior of the Choroid and Its Effect on Ocular Trauma Simulations.Investigative ophthalmology & visual science · 2026Article
- Effects of tissue degradation by collagenase and elastase on the biaxial mechanics of porcine airways.Respiratory research · 2023Article
- Synthesis and characterisation of a cancerous liver for presurgical planning and training applications.BMJ open gastroenterology · 2022Article
- Resuscitative endovascular balloon occlusion of the aorta: rupture risk and implications for blind inflation.Trauma surgery & acute care open · 2018Article
- Preface: Computational and experimental methods for biological research: cardiovascular diseases and beyond.Biomedical engineering online · 2016Article
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3 authors.
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Abstract
objectiveConsidering past studies on the orthotropic anisotropy of arteries in the circumferential and axial directions, this work aims to experimentally study the anisotropic behaviour of arteries by tensioning multi-directional strips of porcine thoracic aorta.
methodsHistology is first analyzed by staining arterial sections of three orthotropic (axial, circumferential, and radial) planes. 168 stripped samples from 21 aortas are categorized into three loading-rate groups to investigate the influence of loading rates on the Young's modulus and ultimate stress. Basing on the Young's modulus and ultimate stress, the degree of anisotropy is calculated. Moreover, 24 stripped samples from 3 aortas are tested to study the relaxation anisotropy of arteries by fitting the experimental data with a five-parameter Maxwell reduced relaxation function.
resultsHistological analysis shows the parallel orientation of crimpled collagen and elastin fibres. The Young's modulus and ultimate stress reach the greatest in the circumferential direction, and the smallest in the axial direction, respectively, and the values in the other directions are in-between; moreover, the two parameters monotonously increase as the samples orientate from the axial to circumferential directions. The Young's modulus is more sensitive to the loading rate than the ultimate stress. The degree of anisotropy calculated by the Young's modulus is similar to that by the ultimate stress, and it is independent of loading rates. Stress-relaxation also exhibits anisotropy, whose variation is consistent with those of the two parameters.
conclusionsDue to the stress-growth rule, fibre preferably orientates in the circumferential direction, and the preferable orientation results in great mechanical parameters, anisotropy, and small relaxation behaviour of arteries. The work extends the studies on the arterial anisotropy instead of only the circumferential and axial directions, and could be useful to comprehensively understand the anisotropy of arteries.
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