ArticleBiomedical engineering online2016
Numerical prediction of thrombus risk in an anatomically dilated left ventricle: the effect of inflow cannula designs.
Article in Biomedical engineering online, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 41 citations in OpenAlex.
- Efficiency and hemodynamics of dual drainage venovenous ECMO: A computational parametric study.PloS one · 2026Article
- Influence of side-hole configuration on recirculation in dual-lumen cannulas for veno-venous extracorporeal membrane oxygenation: a parametric computational fluid dynamics study.Frontiers in bioengineering and biotechnology · 2026Article
- Optimization of flow rate and orientation of outflow graft at implantation for patients with left ventricular assist device.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Influence of LVAD Cannula Outflow Graft Flow Rate and Location on Fluid-Particle Interactions and Thrombi Distribution: A Primary Numerical Study.Journal of cardiovascular translational research · 2024Article
- Optimization of a centrifugal blood pump designed using an industrial method through experimental and numerical study.Scientific reports · 2024Article
- Effects of the atrium on intraventricular flow patterns during mechanical circulatory support.The International journal of artificial organs · 2022Article
- Multi-constituent simulation of thrombus formation at LVAD inlet cannula connection: Importance of Virchow's triad.Artificial organs · 2021Article
- Validation of numerically simulated ventricular flow patterns during left ventricular assist device support.The International journal of artificial organs · 2021Article
- Ventricular Flow Field Visualization During Mechanical Circulatory Support in the Assisted Isolated Beating Heart.Annals of biomedical engineering · 2020Article
- Preface: Computational and experimental methods for biological research: cardiovascular diseases and beyond.Biomedical engineering online · 2016Article
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7 authors at 4 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundImplantation of a rotary blood pump (RBP) can cause non-physiological flow fields in the left ventricle (LV) which may trigger thrombosis. Different inflow cannula geometry can affect LV flow fields. The aim of this study was to determine the effect of inflow cannula geometry on intraventricular flow under full LV support in a patient specific model.
methodsComputed tomography angiography imaging of the LV was performed on a RBP candidate to develop a patient-specific model. Five inflow cannulae were evaluated, which were modelled on those used clinically or under development. The inflow cannulae are described as a crown like tip, thin walled tubular tip, large filleted tip, trumpet like tip and an inferiorly flared cannula. Placement of the inflow cannula was at the LV apex with the central axis intersecting the centre of the mitral valve. Full support was simulated by prescribing 5 l/min across the mitral valve. Thrombus risk was evaluated by identifying regions of stagnation. Rate of LV washout was assessed using a volume of fluid model. Relative haemolysis index and blood residence time was calculated using an Eulerian approach.
resultsThe inferiorly flared inflow cannula had the lowest thrombus risk due to low stagnation volumes. All cannulae had similar rates of LV washout and blood residence time. The crown like tip and thin walled tubular tip resulted in relatively higher blood damage indices within the LV.
conclusionChanges in intraventricular flow due to variances in cannula geometry resulted in different stagnation volumes. Cannula geometry does not appreciably affect LV washout rates and blood residence time. The patient specific, full support computational fluid dynamic model provided a repeatable platform to investigate the effects of inflow cannula geometry on intraventricular flow.
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