ArticleBiomedical engineering online2016
The study on hemodynamic effect of series type LVAD on aortic blood flow pattern: a primary numerical study.
Article in Biomedical engineering online, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Optimization of flow rate and orientation of outflow graft at implantation for patients with left ventricular assist device.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Optimization of a centrifugal blood pump designed using an industrial method through experimental and numerical study.Scientific reports · 2024Article
- Prediction of Stress Map in Ascending Aorta - Optimization of the Coaxial Position in Transcatheter Aortic Valve Replacement.Arquivos brasileiros de cardiologia · 2020Article
- Turbulent Flow Promotes Cleavage of VWF (von Willebrand Factor) by ADAMTS13 (A Disintegrin and Metalloproteinase With a Thrombospondin Type-1 Motif, Member 13).Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Clinical validation and assessment of aortic hemodynamics using computational fluid dynamics simulations from computed tomography angiography.Biomedical engineering online · 2018Article
- Helical Flow Component of Left Ventricular Assist Devices (LVADs) Outflow Improves Aortic Hemodynamic States.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Preface: Computational and experimental methods for biological research: cardiovascular diseases and beyond.Biomedical engineering online · 2016Article
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3 authors.
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Abstract
backgroundLeft ventricular assist device (LVAD) has become an alternative treatment for end-stage heart failure patients. Series type of LVAD, as a novel LVAD, has attracted more and more attention. The hemodynamic effects of series type LVAD on aortic blood pattern are considered as its important characteristics; however, the precise mechanism of it is still unclear.
methodsTo clarify the hemodynamic effects of series type LVAD on aortic blood flow pattern, a comparative study on the aortic blood flow pattern and hemodynamic states were carried out numerically for two cases, including series type LVAD support and normal condition. The steady-state computational fluid dynamic (CFD) approach was employed. The blood flow streamline, blood velocity vector and distribution of wall shear stress (WSS) were calculated to evaluate the differences of hemodynamic effects between both conditions.
resultsThe results demonstrated that the aortic flow pattern under series type LVAD showed significant different from that of normal condition. The strength of aortic swirling flow was significantly enhanced by the series type LVAD support. Meanwhile, the rotating direction of swirling flow under LVAD support was also dominated by the rotating direction of series type LVAD. Moreover, the blood velocity and WSS under LVAD support were also significantly enhanced, compared with that under normal condition.
conclusionThe hemodynamic states, including the aortic swirling flow characteristic, was significantly dominated by LVAD support. Present investigation could provide not only a useful information on the vascular complications caused by LVAD support, but also provide a useful guide for optimal the structure of the series type LVAD.
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