Evidence map›Paper›PMID 28155203›Full record

ArticleInternational journal of bipolar disorders2017

Pilot study of a culturally adapted psychoeducation (CaPE) intervention for bipolar disorder in Pakistan.

Muhammad Ishrat Husain, Imran B Chaudhry, Raza R Rahman, Munir M Hamirani, Nasir Mehmood, Peter M Haddad, John Hodsoll, Allan H Young, Farooq Naeem, Nusrat Husain

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In one paragraph

Article in International journal of bipolar disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02210390 (Feasibility RCT of the Efficacy of a Culturally Adapted Psychological Intervention for Bipolar Disorder in Pakistan), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02210390 nacompletednot on this map

Feasibility RCT of the Efficacy of a Culturally Adapted Psychological Intervention for Bipolar Disorder in Pakistan

TypeinterventionalSponsorPakistan Institute of Living and LearningRan2012 to 2015Enrolled36ConditionsBipolar DisorderArmsPsycho education
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muhammad Ishrat HusainCamden and Islington NHS Foundation Trust, St Pancras Hospital, 4 St Pancras Way, London, NW1 0PE, UK. Ishrat-h@doctors.net.uk.
Imran B ChaudhryPakistan Institute of Living and Learning, Karachi, Sindh, Pakistan.
Raza R RahmanDepartment of Psychiatry, Dow University of Health Sciences, Karachi, Pakistan.
Munir M HamiraniDepartment of Psychiatry, Abbasi Shaheed Hospital, Karachi, Pakistan.
Nasir MehmoodPakistan Institute of Living and Learning, Karachi, Sindh, Pakistan.
Peter M HaddadUniversity of Manchester, Oxford Road, Manchester, UK.
John HodsollCentre for Affective Disorders, Institute of PsychiatryPsychology and Neuroscience, King's College London, London, UK.
Allan H YoungCentre for Affective Disorders, Institute of PsychiatryPsychology and Neuroscience, King's College London, London, UK.
Farooq NaeemDepartment of Psychiatry, Queens' University, Kingston, ON, Canada.
Nusrat HusainUniversity of Manchester, Oxford Road, Manchester, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the use of maintenance medication, recurrence rates in bipolar affective disorder (BPAD) are high. To date, there are no clinical trials that have investigated the use of psychological interventions in bipolar disorder in Pakistan.

aimThe purpose of the study was to assess the feasibility and acceptability of a culturally adapted bipolar psychoeducation programme (CaPE) in Pakistan.

methodsThirty-four euthymic bipolar I and II outpatients were randomized to either 12 weekly sessions of individual psychoeducation plus Treatment As Usual (Intervention) or Treatment As Usual (TAU) (Control). Outcomes were assessed using the Young Mania Rating Scale (YMRS), Beck Depression Inventory (BDI), EuroQoL (EQ-5D), Bipolar Knowledge and Attitudes and Questionnaire (BKAQ), and a self-reported measure of medication adherence (Morisky Medication Adherence Scale-4 items, MMAS-4). Effect sizes were derived from baseline adjusted standardized regression coefficients.

resultsRetention in the study was good, 80% of patients in the TAU follow-up assessment and 100% of patients in the CaPE group attended all 12 sessions. Patient satisfaction was higher in the CaPE group relative to control (ES = 1.41). Further, there were large effect sizes shown for CaPE versus TAU for medication adherence (MMAS-4: ES = 0.81), knowledge and attitudes towards bipolar (BKAQ: ES = 0.68), mania (YMRS: ES = 1.18), depression (BDI: ES = 1.17) and quality of life measures (EQ-5D: ES ⇒ 0.88).

conclusionsCulturally adapted psychoeducation intervention is acceptable and feasible, and can be effective in improving mood symptoms and knowledge and attitudes to BPAD when compared with TAU. Larger scale studies are needed to confirm our findings.

trial registrationClinicaltrials.gov identifier NCT02210390.

Indexed as

Bipolar disorderCultural psychiatryPakistanPsychoeducation

Identifiers

PMID28155203
PMCPMC5307423

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