Evidence map›Paper›PMID 28155102›Full record

Observational studySleep & breathing = Schlaf & Atmung2017

Stratification of cardiovascular risk in patients with atrial fibrillation and obstructive sleep apnea-validity of the 2MACE score.

Anna E Platek, Filip M Szymanski, Krzysztof J Filipiak, Alicja Dudzik-Plocica, Bartosz Krzowski, Grzegorz Karpinski

Abstract readObservational StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Sleep & breathing = Schlaf & Atmung, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Guideline
  4. Article
  5. Exploring the bidirectional relationship between sleep disorders and atrial fibrillation: implications for risk stratification and management.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024
    Review
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna E Platek1st Department of Cardiology, Medical University of Warsaw, 1A Banacha Street, 02-097, Warsaw, Poland. anna.platek@wum.edu.pl.
Filip M Szymanski1st Department of Cardiology, Medical University of Warsaw, 1A Banacha Street, 02-097, Warsaw, Poland.
Krzysztof J Filipiak1st Department of Cardiology, Medical University of Warsaw, 1A Banacha Street, 02-097, Warsaw, Poland.
Alicja Dudzik-Plocica1st Department of Cardiology, Medical University of Warsaw, 1A Banacha Street, 02-097, Warsaw, Poland.
Bartosz Krzowski1st Department of Cardiology, Medical University of Warsaw, 1A Banacha Street, 02-097, Warsaw, Poland.
Grzegorz Karpinski1st Department of Cardiology, Medical University of Warsaw, 1A Banacha Street, 02-097, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRisk stratification in patients with atrial fibrillation (AF) is critically important because this group is at high risk of mortality and morbidity. One of the comorbidities potentially affecting thromboembolic and total cardiovascular risk is obstructive sleep apnea (OSA). The aim of this study was to determine whether or not patients with atrial fibrillation and concomitant obstructive sleep apnea have a higher predicted cardiovascular risk than those without sleep-disordered breathing.

methodsThe study was designed to be a cross-sectional observational study. Consecutive patients with primary diagnosis of AF who qualified for first-ever catheter ablation between 2011 and 2013 were enrolled. All patients had an overnight polysomnography performed for the diagnosis of OSA and calculation of a 2MACE score-a cardiovascular risk assessment score for AF.

resultsWe studied 211 AF patients (mean age 57.1 ± 10.2 years, 62.6% males). OSA with apnea-hypopnea index (AHI) ≥15/h was found in 48 patients (22.7%). Cardiovascular disease and risk factors were as follows: 8 (3.8%) patients had congestive heart failure, 27 (12.8%) diabetes, 16 (7.6%) history of stroke or thromboembolic disease, 194 (91.9%) arterial hypertension, 24 (11.4%) vascular disease, and 31 (14.7%) were current smokers. A significantly higher percentage of patients with OSA was at high risk of cardiovascular disease (29.2 vs. 8.1%; p < 0.0001). The trend remained significant in different categories of obstructive sleep apnea when categorized by AHI into non-OSA, and mild, moderate, and severe OSA. Similarly, the mean 2MACE score was statistically significantly higher in OSA than non-OSA patients (2.1 ± 1.1 vs. 1.4 ± 1.0; p < 0.0001).

conclusionOSA prevalence is increased in AF patients and is associated with an increase 2MACE score-an indicator of major cardiovascular events. There is a linear relationship between severity of OSA and increasing 2MACE scores, indicating increasing cardiovascular risk related to OSA severity.

Indexed as

AgedAtrial FibrillationCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk AssessmentSleep Apnea, ObstructiveCardiovascular riskObstructive sleep apneaRisk assessment

Identifiers

PMID28155102
PMCPMC5585292

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.