ReviewJournal of materials science. Materials in medicine2017
A review on animal models and treatments for the reconstruction of Achilles and flexor tendons.
Review in Journal of materials science. Materials in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Immortalized Rat Tendon-Derived Stem Cells for Tendon Tissue Engineering.Bioengineering (Basel, Switzerland) · 2026Article
- Regeneration of Biomechanically Functional Tendon Tissue Following Injection of Uncultured, Autologous, Adipose-Derived Regenerative Cells into Partial Achilles Tendon Defects in Rabbits.International journal of molecular sciences · 2025Article
- Article
- Replacement of tibialis cranialis tendon with polyester, silicone-coated artificial tendon preserves biomechanical function in rabbits compared to tendon excision only.Journal of orthopaedic surgery and research · 2024Article
- Collagen scaffold-seeded iTenocytes accelerate the healing and functional recovery of Achilles tendon defects in a rat model.Frontiers in bioengineering and biotechnology · 2024Article
- iPSC-derived tenocytes seeded on microgrooved 3D printed scaffolds for Achilles tendon regeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Ex Vivo Biomechanical Assessment of Various Repair Techniques in a Rabbit Calcaneal Tendon Avulsion Model: Application of Polycaprolactone Plate.Veterinary sciences · 2023Article
- Immortalized murine tenocyte cells: a novel and innovative tool for tendon research.Scientific reports · 2023Article
- Comparison of cortical versus cancellous bone fixation in tendon-to-bone healing with a rat trans-calcaneal suture model for Achilles tendon sleeve avulsion.Journal of orthopaedic surgery and research · 2023Article
- Poly (trimethylene carbonate)/doxycycline hydrochloride films in the treatment of Achilles tendon defect in rats.Frontiers in bioengineering and biotechnology · 2023Article
- A Simplified Murine Model to Imitate Flexor Tendon Adhesion Formation without Suture.Biomimetics (Basel, Switzerland) · 2022Article
- Comparison of the Effects of Open Surgery and Minimally Invasive Surgery on the Achilles Tendon Rupture Healing Based on Angiogenesis.Computational intelligence and neuroscience · 2022Article
- Large animal models for the study of tendinopathy.Frontiers in cell and developmental biology · 2022Review
- Muscular and Tendon Degeneration after Achilles Rupture: New Insights into Future Repair Strategies.Biomedicines · 2021Article
- Autologous bone marrow-derived mesenchymal stem cells provide complete regeneration in a rabbit model of the Achilles tendon bundle rupture.International orthopaedics · 2021Article
- Species variations in tenocytes' response to inflammation require careful selection of animal models for tendon research.Scientific reports · 2021Article
- Review
- Microsurgical reconstruction affects the outcome in a translational mouse model for Achilles tendon healing.Journal of orthopaedic translation · 2020Article
- The cellular basis of fibrotic tendon healing: challenges and opportunities.Translational research : the journal of laboratory and clinical medicine · 2019Review
- Achilles Tendon Repair by Decellularized and Engineered Xenografts in a Rabbit Model.Stem cells international · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tendon is a connective tissue mainly composed of collagen fibers with peculiar mechanical properties essential to functional movements. The increasing incidence of tendon traumatic injuries and ruptures-associated or not with the loss of tissue-falls on the growing interest in the field of tissue engineering and regenerative medicine. The use of animal models is mandatory to deepen the knowledge of the tendon healing response to severe damages or acute transections. Thus, the selection of preclinical models is crucial to ensure a successful translation of effective and safe innovative treatments to the clinical practice. The current review is focused on animal models of tendon ruptures and lacerations or defective injuries with large tissue loss that require surgical approaches or grafting procedures. Data published between 2000 and 2016 were examined. The analyzed articles were compiled from Pub Med-NCBI using search terms, including animal model(s) AND tendon augmentation OR tendon substitute(s) OR tendon substitution OR tendon replacement OR tendon graft(s) OR tendon defect(s) OR tendon rupture(s). This article presents the existing preclinical models - considering their advantages and disadvantages-in which translational progresses have been made by using bioactive sutures or tissue engineering that combines biomaterials with cells and growth factors to efficiently treat transections or large defects of Achilles and flexor tendons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.