ArticleEcotoxicology (London, England)2017
The use of minimum selectable concentrations (MSCs) for determining the selection of antimicrobial resistant bacteria.
Article in Ecotoxicology (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Feeding the invaders: how metabolic imbalance shapes infection and biofilm development.FEMS microbiology reviews · 2026Review
- Toward standardized environmental detection of antibiotics and ARGs for regulatory interpretation and concern tiering.Frontiers in microbiology · 2026Review
- Impacts of environmentally relevant concentrations of antibiotic cocktails on the skin microbiome of Eurasian carp (Cyprinus carpio).Animal microbiome · 2025Article
- Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance.The ISME journal · 2025Article
- Synergizing Ecotoxicology and Microbiome Data Is Key for Developing Global Indicators of Environmental Antimicrobial Resistance.Microbial ecology · 2024Review
- Ciprofloxacin Concentrations in Food Could Select for Quinolone Resistance inAntibiotics (Basel, Switzerland) · 2024Article
- In Vitro Resistance-Predicting Studies and In Vitro Resistance-Related Parameters-A Hit-to-Lead Perspective.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Interspecies interaction reduces selection for antibiotic resistance in Escherichia coli.Communications biology · 2023Article
- In Vitro Investigation of the Antibacterial Activity of Nine Commercial Water Disinfectants, Acidifiers, and Glyceride Blends against the Most Important Poultry Zoonotic Bacteria.Pathogens (Basel, Switzerland) · 2023Article
- Need for standardization in sub-lethal antibiotics research.Frontiers in microbiology · 2023Review
- Variability in Adaptive Resistance ofAntibiotics (Basel, Switzerland) · 2022Article
- River Biofilms Microbiome and Resistome Responses to Wastewater Treatment Plant Effluents Containing Antibiotics.Frontiers in microbiology · 2022Article
- A Microfluidic Chip for Studies of the Dynamics of Antibiotic Resistance Selection in Bacterial Biofilms.Frontiers in cellular and infection microbiology · 2022Article
- Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 1:EFSA journal. European Food Safety Authority · 2021Article
- Machine Learning Prediction of Resistance to Subinhibitory Antimicrobial Concentrations from Escherichia coli Genomes.mSystems · 2021Article
- Identification of Antibiotics in Surface-Groundwater. A Tool towards the Ecopharmacovigilance Approach: A Portuguese Case-Study.Antibiotics (Basel, Switzerland) · 2021Article
- The highly dynamic nature of bacterial heteroresistance impairs its clinical detection.Communications biology · 2021Article
- Effects of monochloramine on culturability, viability and persistence of Pseudomonas putida and tap water mixed bacterial community.Applied microbiology and biotechnology · 2021Article
- Acceleration of emergence of E. coli antibiotic resistance in a simulated sublethal concentration of copper and tetracycline co-contaminated environment.AMB Express · 2021Article
- A Risk-Based Approach for Managing Aquaculture Used Oxytetracycline-Induced TetR in Surface Water Across Taiwan Regions.Frontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of antimicrobial compounds is indispensable in many industries, especially drinking water production, to eradicate microorganisms. However, bacterial growth is not unusual in the presence of disinfectant concentrations that would be typically lethal, as bacterial populations can develop resistance. The common metric of population resistance has been based on the Minimum Inhibitory Concentration (MIC), which is based on bacteria lethality. However, sub-lethal concentrations may also select for resistant bacteria due to the differences in bacterial growth rates. This study determined the Minimal Selective Concentrations (MSCs) of bacterial populations exposed to free chlorine and monochloramine, representing a metric that possibly better reflects the selective pressures occurring at lower disinfectant levels than MIC. Pairs of phylogenetically similar bacteria were challenged to a range of concentrations of disinfectants. The MSCs of free chlorine and monochloramine were found to range between 0.021 and 0.39 mg L
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