Evidence map›Paper›PMID 28154995›Full record

ArticleClinical oral investigations2017

Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry?

Richard J Miron, Masako Fujioka-Kobayashi, Maria Hernandez, Umadevi Kandalam, Yufeng Zhang, Shahram Ghanaati, Joseph Choukroun

7 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 277 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
277citing papers in PubMed, 11 pooled it
32.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03698188 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Evaluation of the Efficacy of Injectable Platelet-Rich Fibrin Versus Platelet-Rich Plasma in the Regeneration of Necrotic Immature Maxillary Anterior Teeth. (A Randomized Clinical Trial)

TypeinterventionalSponsorCairo UniversityRan2018 to 2020Enrolled24ConditionsNecrotic PulpArmsInjectable platelet-rich fibrin, Platelet-rich plasma
NCT03839849 nacompletednot on this mapstarted 2019, after this paper: background citation

Clinical Effectiveness of a Topical Subgingival Application of Injectable Platelet-rich Fibrin as Adjunctive Therapy to Scaling and Root Planing. A Double-blind Split Mouth Randomized Prospective Comparative Controlled Trial

TypeinterventionalSponsorSyrian Private UniversityRan2019 to 2019Enrolled15ConditionsPeriodontal PocketsArms: i-PRF, saline
NCT04313010 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Effectiveness of Regenerative Endodontics Therapy for Single-rooted Mature Permanent Tooth With Pulp Necrosis: a Multicenter Randomized Controlled Clinical Trial.

TypeinterventionalSponsorSouthern Medical University, ChinaRan2020 to 2024Enrolled346ConditionsPulp NecrosisArmsPRF, BC
NCT05753631 completednot on this mapstarted 2022, after this paper: background citation

Evaluation of the Effects of Injectable Platelet-rich Fibrin (i-PRF) Application on Periodontal Clinical and Biochemical Parameters in Gingival Crevicular Fluid (GCF) in Non-surgical Periodontal Treatment

Typeobservational_patient_registrySponsorPamukkale UniversityRan2022 to 2023Enrolled24ConditionsPlatelet-Rich FibrinArmsnon surgical periodontal treatment
NCT05766618 phase3unknown statusnot on this mapstarted 2023, after this paper: background citation

The Effect of Multiple Injections of Platelets Rich Fibrin (i-PRF) on The Rate of Canine Retraction A Split-mouth: A Randomized Controlled Trial

TypeinterventionalSponsorCairo UniversityRan2023 to 2024Enrolled22ConditionsPlatelet-Rich Fibrin, Acceleration, OrthodonticsArmsInjectable platelet rich fibrin (i-PRF): in acceleration of orthodontic tooth movement
NCT06304935 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effect of the Injectable Platelet Rich Fibrin After Tonsillectomy on Wound Healing Hemostasis and Post Operative Pain

TypeinterventionalSponsorAssiut UniversityRan2024 to 2025Enrolled100ConditionsIPRF Post TonsillectomyArmsUse of injectable platelet rich fibrin after tonsillectomy by injection of IPRF in one tonsillar bed and use of other side as control
NCT06753396 narecruitingnot on this mapstarted 2022, after this paper: background citation

Evaluation of the Effect of Injectable Platelet-Rich Fibrin on Peri-Implant Soft Tissue Phenotype

TypeinterventionalSponsorKutahya Health Sciences UniversityRan2022 to 2026Enrolled80ConditionsPeri-Implant TissuesArmsPlatelet rich fibrin
3 · Its place in the literature

Who cites it

277 citing papers in PubMed, 11 syntheses or guidelines pooled it, 537 citations in OpenAlex.

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  10. Utilization and efficacy of platelet-rich plasma and platelet-rich fibrin in otolaryngology: a systematic evidence-based review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
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217 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 5 countries.

Richard J MironDepartment of Periodontology, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA. rmiron@nova.edu.
Masako Fujioka-KobayashiDepartment of Periodontology, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA.
Maria HernandezDepartment of Periodontology, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA.
Umadevi KandalamDepartment of Pediatric Dentistry, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA.
Yufeng ZhangDepartment of Oral Implantology, University of Wuhan, Wuhan, China.
Shahram GhanaatiFORM, Frankfurt Oral Regenerative Medicine, Clinic for Maxillofacial and Plastic Surgery, Johann Wolfgang Goethe University, Frankfurt Am Main, Germany.
Joseph ChoukrounPain Clinic, Nice, France.
Nova Southeastern University · USGoethe University Frankfurt · DEWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPlatelet rich plasma (PRP) has been utilized in regenerative dentistry as a supra-physiological concentrate of autologous growth factors capable of stimulating tissue regeneration. Despite this, concerns have been expressed regarding the use of anti-coagulants, agents known to inhibit wound healing. In this study, a liquid formulation of platelet rich fibrin (PRF) termed injectable-PRF (i-PRF) without the use of anti-coagulants was investigated. MATERIALS AND

methodsStandard PRP and i-PRF (centrifuged at 700 rpm (60G) for 3 min) were compared for growth factor release up to 10 days (8 donor samples). Furthermore, fibroblast biocompatibility at 24 h (live/dead assay); migration at 24 h; proliferation at 1, 3, and 5 days, and expression of PDGF, TGF-β, and collagen1 at 3 and 7 days were investigated.

resultsGrowth factor release demonstrated that in general PRP had higher early release of growth factors whereas i-PRF showed significantly higher levels of total long-term release of PDGF-AA, PDGF-AB, EGF, and IGF-1 after 10 days. PRP showed higher levels of TGF-β1 and VEGF at 10 days. While both formulations exhibited high biocompatibility and higher fibroblast migration and proliferation when compared to control tissue-culture plastic, i-PRF induced significantly highest migration whereas PRP demonstrated significantly highest cellular proliferation. Furthermore, i-PRF showed significantly highest mRNA levels of TGF-β at 7 days, PDGF at 3 days, and collagen1 expression at both 3 and 7 days when compared to PRP.

conclusionsi-PRF demonstrated the ability to release higher concentrations of various growth factors and induced higher fibroblast migration and expression of PDGF, TGF-β, and collagen1. Future animal research is now necessary to further validate the use of i-PRF as a bioactive agent capable of stimulating tissue regeneration. CLINICAL RELEVANCE: The findings from the present study demonstrate that a potent formulation of liquid platelet concentrates could be obtained without use of anti-coagulants.

Indexed as

Platelet-Rich FibrinBiocompatible MaterialsCell Culture TechniquesCell MovementCell ProliferationCell SurvivalEnzyme-Linked Immunosorbent AssayFibroblastsIntercellular Signaling Peptides and ProteinsReal-Time Polymerase Chain ReactionRegenerationBiocompatible MaterialsIntercellular Signaling Peptides and ProteinsBlood plateletsFibrinFibroblastsPlatelet rich fibrinRegenerationWound healing

Identifiers

PMID28154995
OpenAlexW2584707707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.