ArticleEuropean journal of applied physiology2017
ACTN3 genotype influences exercise-induced muscle damage during a marathon competition.
Article in European journal of applied physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- ACTN3 c.1729C>T Polymorphism Might Not Be a Standalone Factor in Non-contact Musculoskeletal Injury: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- The frequency of the ACTN3 polymorphism in Brazil: a systematic review and meta-analysis.BMC medical genomics · 2025Pooled it
- A Systematic Review and Meta-analysis of the Association Between ACTN3 R577X Genotypes and Performance in Endurance Versus Power Athletes and Non-athletes.Sports medicine - open · 2024Pooled it
- Association between ACTN3 R577X genotype and risk of non-contact injury in trained athletes: A systematic review.Journal of sport and health science · 2023Pooled it
- Wheel Diameter Affects Vibration Transmission but Not Performance During Uphill and Downhill Mountain Biking over Rough Terrain.Methods and protocols · 2026Article
- The X genotype of the ACTN3 sports gene is associated with the endurance of the sportsperson from the South Indian population: a short study.European journal of applied physiology · 2026Article
- Reevaluating the total genotype score: a practical perspective from applied sport science.Journal of applied genetics · 2025Article
- Review
- The Distribution of Sport Performance Gene Variations Through COVID-19 Disease Severity.Diagnostics (Basel, Switzerland) · 2025Article
- Association of alpha-actinin-3 genotype with muscle mass and physical function in community-dwelling older adults.European geriatric medicine · 2025Article
- Genomic information in the decision-making process for the training of a high-performance brazilian swimmer: a case report.Frontiers in genetics · 2025Article
- Impact of ACTN3 R577X Polymorphism on Muscle Damage Susceptibility Following Aerobic or Strength Exercises: A Systematic Review.International journal of preventive medicine · 2025Review
- The Genetic Basis of Non-Contact Soft Tissue Injuries-Are There Practical Applications of Genetic Knowledge?Cells · 2024Review
- Genetic Variations in Susceptibility to Traumatic Muscle Injuries and Muscle Pain among Brazilian High-Performance Athletes.International journal of molecular sciences · 2024Article
- Genotype Distribution of theGenes · 2022Article
- Association of theGenes · 2022Article
- Acute rhabdomyolysis in hepatitis-associated aplastic anemia patient undergoing allogeneic hematopoietic stem-cell transplantation: case report and literature review.European journal of medical research · 2022Review
- Influence of Alpha-Actinin-3 R577X Polymorphism on Muscle Damage and the Inflammatory Response after an Acute Strength Training Session.BioMed research international · 2022Article
- Article
- Supplementation with Vitamins C and E and Exercise-Induced Delayed-Onset Muscle Soreness: A Systematic Review.Antioxidants (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeExercise-induced muscle damage has been identified as one of the main causes of the progressive decrease in running and muscular performance in marathoners. The aim of this investigation was to determine the influence of the ACTN3 genotype on exercise-induced muscle damage produced during a marathon.
methodsSeventy-one experienced runners competed in a marathon race. Before and after the race, a sample of venous blood was obtained and maximal voluntary leg muscle power was measured during a countermovement jump. In the blood samples, the ACTN3 genotype (R577X) and the changes in serum creatine kinase and myoglobin concentrations were measured. Data from RX heterozygotes and XX mutant homozygotes were grouped as X allele carriers and compared to RR homozygotes.
resultsAt the end of the race, X allele carriers presented higher serum myoglobin (774 ± 852 vs 487 ± 367 U L
conclusionsIn comparison to RR homozygotes, X allele carriers for the R577X polymorphism of the ACTN3 gene presented higher values for typical markers of exercise-induced muscle damage during a competitive marathon. Thus, the absence of a functional α-actinin-3 produced by the X allele might induce higher levels of muscle breakdown during prolonged running events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.