Observational studyPediatric surgery international2017
Diagnostic value of the preoperatively detected radiological transition zone in Hirschsprung's disease.
Observational study in Pediatric surgery international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Evaluation of Trans-Anal Endorectal Pull-Through Outcomes in Hirschsprung's Disease in Different Age Groups: A Comprehensive Systematic Review.Archives of Iranian medicine · 2024Pooled it
- Systematic appraisal of the guidelines for the diagnosis and treatment of Hirschsprung's disease.Pediatric surgery international · 2022Pooled it
- Automatic ganglion cell detection for improving the efficiency and accuracy of hirschprung disease diagnosis.Scientific reports · 2021Trial
- Predictive role of ultrasonography in the early diagnosis of Hirschsprung's disease in neonates and infants: an observational diagnostic study.Emergency radiology · 2026Observational
- Development and clinical assessment of a novel AI-based diagnostic model for Hirschsprung's disease.Updates in surgery · 2026Article
- Article
- Intra-operative application of ultra-high frequency ultrasound facilitates differentiation of bowel wall characteristics between ganglionic and aganglionic segments during transanal endorectal pull-through for Hirschsprung disease.Communications medicine · 2026Article
- Early Outcomes of Hirschsprung's Disease after Definitive Surgery: A Ten-year Experience.Current pediatric reviews · 2025Article
- Plasma NMDAR autoantibody: a new biomarker for the diagnosis of Hirschsprung disease.Frontiers in pediatrics · 2025Article
- Hirschsprung disease at a tertiary hospital: Patient profile, management and outcomes.Health SA = SA Gesondheid · 2025Article
- High-Resolution Anorectal Manometry as a Screening Tool for Hirschsprung's Disease: A Comprehensive Retrospective Analysis.Journal of clinical medicine · 2024Article
- Diagnostic accuracy of barium enema versus full-thickness rectal biopsy in children with clinically suspected Hirschsprung's disease: A comparative cross-sectional study.Health science reports · 2024Article
- Single-stage Transanal Endorectal Pull-Through for Hirschsprung's Disease: A Retrospective Study of Surgico-pathological Correlations and Technical Considerations.African journal of paediatric surgery : AJPS · 2023Article
- The Prevalence and Clinical Impact of Transition Zone Anastomosis in Hirschsprung Disease: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2023Review
- Screening of undernutrition in children with Hirschsprung disease using preoperative anthropometric parameters: A multicenter cross-sectional study.JPEN. Journal of parenteral and enteral nutrition · 2023Article
- The utility of the 24-h delayed film of barium enema for detecting the dysganglionic bowel segment in Hirschsprung's disease.Frontiers in pediatrics · 2022Article
- Development of Clinical Referral Score Model for Early Diagnosis of Hirschsprung's Disease in Suspected Pediatric Patients.Healthcare (Basel, Switzerland) · 2021Article
- Laparoscopic vs. Transabdominal Treatment for Overflow Fecal Incontinence Due to Residual Aganglionosis or Transition Zone Pathology in Hirschsprung's Disease Reoperation.Frontiers in pediatrics · 2021Article
- Long-term outcomes of single-incision laparoscopic technique in Soave procedure compared with heart-shaped anastomosis for Hirschsprung disease.International journal of colorectal disease · 2020Article
- Accuracy of colonic mucosal patterns at contrast enema for diagnosis of Hirschsprung disease.Pediatric radiology · 2020Article
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveThe cardinal diagnostic sign of congenital aganglionic megacolon, or Hirschsprung's disease (HD), is an aganglionic segment of the distal colon or rectum. To determine the surgical planning of a radiological transition zone (TZ) in HD, this study investigated the association between a radiological TZ and the bowel resection length.
methodsA prospective observational study was conducted in children (n = 192) with suspected HD determined by radiological TZ on contrast barium enema, and who underwent pull-through operations. The bowel resection length was ≥10 cm above the proximal radiological TZ levels and confirmed by intraoperative frozen sections. In the contrast enema, the presence and level of a radiological TZ were recorded. Correlation of the TZ features with ganglion cells assessed by immunostaining of neuronal nuclei (NeuN) and the odds ratio were calculated.
resultsThe sensitivity and specificity for diagnosing HD by the presence of a radiological TZ were 86.9 and 92.1%, respectively; Youden's index was 79.0%. The positive and negative predictive values were 91.7 and 87.6%. The kappa value indicating an association between TZ and HD was 0.776 (P < 0.05). The correlation rate between a radiological TZ and the pathological results was 88.5% in the rectosigmoid colon and 44.4% in the descending colon, and was higher in children older than 3 months (85.3%) than in infants (69.0%).
conclusionA preoperatively determined radiological TZ has potential value to identify the length of resected bowel in patients with HD, and it also has a high predictive value for diagnosis of HD.
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