Evidence map›Paper›PMID 28154902›Full record

ReviewPediatric surgery international2017

Guidelines for the diagnosis and management of Hirschsprung-associated enterocolitis.

Ankush Gosain, Philip K Frykman, Robert A Cowles, John Horton, Marc Levitt, David H Rothstein, Jacob C Langer, Allan M Goldstein, American Pediatric Surgical Association Hirschsprung Disease Interest Group

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pediatric surgery international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Guideline
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  6. Probiotics for the prevention of Hirschsprung-associated enterocolitis.The Cochrane database of systematic reviews · 2022
    Pooled it
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  10. Trial
  11. Trial
  12. Review
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  14. Review
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  17. Review
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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ankush GosainDivision of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA. agosain@uthsc.edu.ORCID http://orcid.org/0000-0002-0428-1503
Philip K FrykmanDivision of Pediatric Surgery and Departments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Robert A CowlesSection of Pediatric Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.
John HortonMadigan Army Medical Center, Tacoma, WA, USA.
Marc LevittCenter for Colorectal and Pelvic Reconstruction, Nationwide Children's Hospital, Columbus, OH, USA.
David H RothsteinDepartment of Pediatric Surgery, Women and Children's Hospital of Buffalo, Buffalo, NY, USA.
Jacob C LangerDivision of General and Thoracic Surgery, Hospital for Sick Children, Department of Surgery, University of Toronto, Toronto, Canada.
Allan M GoldsteinDepartment of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Warren 1151, Boston, MA, 02114, USA. agoldstein@partners.org.
American Pediatric Surgical Association Hirschsprung Disease Interest Group

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Gastrointestinal Mucosal Immune Defects in Hirschsprungs DiseaseK08DK098271 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI GOSAIN, ANKUSH · 2014 to 2018
$815k
Bacterial and Fungal Dysbiosis in Hirschsprung-Associated EnterocolitisR03DK104040 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI FRYKMAN, PHILIP KENT · 2016 to 2017
$175k
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS K08 DK098271NIDDK NIH HHS R03 DK104040
6 · The paper itself

Abstract

backgroundPatients with Hirschsprung disease are at risk for Hirschsprung-associated enterocolitis (HAEC), an inflammatory disorder of the bowel that represents the leading cause of serious morbidity and death in these patients. The diagnosis of HAEC is made based on clinical signs and symptoms which are often non-specific, making it difficult to establish a definitive diagnosis in many patients. The purpose of this guideline is to present a rational, expert-based approach to the diagnosis and management of HAEC.

methodsThe American Pediatric Surgical Association Board of Governors established a Hirschsprung Disease Interest Group. Group discussions, literature review, and expert consensus were then used to summarize the current state of knowledge regarding diagnosis, management, and prevention of Hirschsprung-associated enterocolitis (HAEC).

resultsGuidelines for the diagnosis of HAEC and its clinical grade, utilizing clinical history, physical examination findings, and radiographic findings, are presented. Treatment guidelines, including patient disposition, diet, antibiotics, rectal irrigations and surgery, are presented.

conclusionsClear, standardized definitions of Hirschsprung-associated enterocolitis and its treatment are lacking in the literature. This guideline serves as a first step toward standardization of diagnosis and management. LEVEL OF EVIDENCE: V.

Indexed as

Anti-Bacterial AgentsEnterocolitisFemaleHirschsprung DiseaseHumansIntestinesMalePhysical ExaminationPractice Guidelines as TopicTherapeutic IrrigationAnti-Bacterial AgentsEnterocolitisHirschsprung-associated enterocolitisHirschsprung diseaseHirschsprung’s-associated enterocolitisHirschsprung’s disease

Identifiers

PMID28154902
PMCPMC5395325

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.