ArticleFrontiers in cellular neuroscience2017
Deletion of Type 3 Adenylyl Cyclase Perturbs the Postnatal Maturation of Olfactory Sensory Neurons and Olfactory Cilium Ultrastructure in Mice.
Article in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 221 citations in OpenAlex.
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- Anti-miR-141-3p maintains homeostasis between autophagy and apoptosis by targeting Yy1 in the fetal lumbosacral defecation center of rats.Molecular therapy. Nucleic acids · 2024Article
- Activity-dependent formation of the topographic map and the critical period in the development of mammalian olfactory system.Genesis (New York, N.Y. : 2000) · 2024Review
- ADCY3: the pivotal gene in classical ketogenic diet for the treatment of epilepsy.Frontiers in cellular neuroscience · 2024Article
- The role of a ciliary GTPase in the regulation of neuronal maturation of olfactory sensory neurons.Development (Cambridge, England) · 2023Article
- Olfactory dysfunction in COVID-19: new insights into the underlying mechanisms.Trends in neurosciences · 2023Review
- The role of ciliopathy-associated type 3 adenylyl cyclase in infanticidal behavior in virgin adult male mice.iScience · 2022Article
- Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles.Communications biology · 2022Review
- Physiological roles of mammalian transmembrane adenylyl cyclase isoforms.Physiological reviews · 2022Review
- Expression and functions of adenylyl cyclases in the CNS.Fluids and barriers of the CNS · 2022Review
- Transcriptome Analysis Reveals Olfactory System Expression Characteristics of Aquatic Snakes.Frontiers in genetics · 2022Article
- Adenylyl cyclase 3 regulates osteocyte mechanotransduction and primary cilium.Biochemical and biophysical research communications · 2021Article
- WNT Signaling Is a Key Player in Alzheimer's Disease.Handbook of experimental pharmacology · 2021Article
- Maturation of the Olfactory Sensory Neuron and Its Cilia.Chemical senses · 2020Review
- [Progress in research on olfactory epithelial regeneration].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 3 adenylyl cyclase (Adcy3) is localized to the cilia of olfactory sensory neurons (OSNs) and is an essential component of the olfactory cyclic adenosine monophosphate (cAMP) signaling pathway. Although the role of this enzyme in odor detection and axonal projection in OSNs was previously characterized, researchers will still have to determine its function in the maturation of postnatal OSNs and olfactory cilium ultrastructure. Previous studies on newborns showed that the anatomic structure of the main olfactory epithelium (MOE) of
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