Evidence map›Paper›PMID 28154508›Full record

ArticleGenomics & informatics2016

Comparison of Two Meta-Analysis Methods: Inverse-Variance-Weighted Average and Weighted Sum of Z-Scores.

Cue Hyunkyu Lee, Seungho Cook, Ji Sung Lee, Buhm Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genomics & informatics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 28 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 28 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 28 syntheses or guidelines pooled it.

  1. Hepatitis B Virus Reactivation Risk With IL-17, IL-23/IL-12, or JAK Inhibitors: A Systematic Review and Meta-Analysis.Liver international : official journal of the International Association for the Study of the Liver · 2026
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  8. Long-Term PMAnnals of the American Thoracic Society · 2025
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  15. Endoscopic Submucosal Dissection Versus Surgery or Endoscopic Mucosal Resection for Metachronous Early Gastric Cancer: a Meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
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  19. Differential gene expression in nasal airway epithelium from overweight or obese youth with asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
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103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cue Hyunkyu LeeAsan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.; Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul 05505, Korea.
Seungho CookAsan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.; School of Systems Biomedical Science, Soongsil University, Seoul 06978, Korea.
Ji Sung LeeAsan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.; Department of Medicine, University of Ulsan College of Medicine, Seoul 05505, Korea.
Buhm HanAsan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.; Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul 05505, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The meta-analysis has become a widely used tool for many applications in bioinformatics, including genome-wide association studies. A commonly used approach for meta-analysis is the fixed effects model approach, for which there are two popular methods: the inverse variance-weighted average method and weighted sum of z-scores method. Although previous studies have shown that the two methods perform similarly, their characteristics and their relationship have not been thoroughly investigated. In this paper, we investigate the optimal characteristics of the two methods and show the connection between the two methods. We demonstrate that the each method is optimized for a unique goal, which gives us insight into the optimal weights for the weighted sum of z-scores method. We examine the connection between the two methods both analytically and empirically and show that their resulting statistics become equivalent under certain assumptions. Finally, we apply both methods to the Wellcome Trust Case Control Consortium data and demonstrate that the two methods can give distinct results in certain study designs.

Indexed as

fixed effects modelgenome-wide association studyinverse variance-weighted averagemeta-analysisoptimalityweighted sum of z-scores

Identifiers

PMID28154508
PMCPMC5287121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.