ArticleClinical gerontologist2017
Determinants of Capacity to Consent to Research on Alzheimer's disease.
Article in Clinical gerontologist, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Enhancing Consent for Alzheimer's Research
Decision-making, Ethical Consent, and Interactive Dialogue in Ongoing Neurocognitive Decline - DECISION
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Multimedia Aided Consent for Alzheimer's Disease Research.Clinical gerontologistTrial
- Informed consent: Navigating the bioethical complexities of clinical research.Bioinformation · 2025Article
- An Iterative Participatory Design Approach to Develop Collaborative Augmented Reality Activities for Older Adults in Long-Term Care Facilities.Proceedings of the SIGCHI conference on human factors in computing systems. CHI Conference · 2024Article
- Cognitive determinants of decisional capacity in neurodegenerative disorders.Annals of clinical and translational neurology · 2023Article
- Ethical analysis of vulnerabilities in cluster randomized trials involving people living with dementia in long-term care homes.Journal of the American Geriatrics Society · 2023Article
- How to deal with the consent of adults with cognitive impairment involved in European geriatric living labs?Philosophy, ethics, and humanities in medicine : PEHM · 2021Review
- Decision-Making Support for People With Alzheimer's Disease: A Narrative Review.Frontiers in psychology · 2021Review
- Determining medical decision-making capacity in brain tumor patients: why and how?Neuro-oncology practice · 2020Review
- Decisional Capacity for Informed Consent in Males and Females with Fragile X Syndrome.Journal of autism and developmental disorders · 2020Article
- Planning Ahead for Dementia Research Participation: Insights from a Survey of Older Australians and Implications for Ethics, Law and Practice.Journal of bioethical inquiry · 2019Article
- A Tale of Two Capacities: Including Children and Decisionally Vulnerable Adults in Biomedical Research.Frontiers in genetics · 2019Article
- Inter-method and anatomical correlates of episodic memory tests in the Alzheimer's Disease spectrum.PloS one · 2019Article
- Using iterative learning to improve understanding during the informed consent process in a South African psychiatric genomics study.PloS one · 2017Article
- Assessing capacity to consent for research in cognitively impaired older patients.Clinical interventions in aging · 2017Review
- Mandating Evidence-Based Informed Consent Practices: A Critical Engagement with IRB Leader Focus Group Findings.Ethics & human researchArticle
- Theory, Science, and Practice for Advancing Capacity Evaluation in Older Adults.Clinical gerontologistArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveInvestigators conducting Alzheimer's disease (AD) research need to consider participants' capacity to consent. Cognitive functioning is a significant predictor of decisional capacity, but there is a dearth of information on the influence of neuropsychiatric symptoms in AD on decisional capacity. We examined the rates of decisional capacity associated with two types of research protocols, and the association of capacity with neuropsychiatric symptoms and other participant characteristics.
methodsWe comprehensively evaluated decisional capacity among 64 patients with mild-to-moderate AD and 70 healthy comparison (HC) subjects randomized to consider either a medium risk or higher risk hypothetical research protocol. Additional measures included sociodemographics, cognitive deficits, and neuropsychiatric symptoms.
resultsTwenty AD patients (31.3%) and 67 HCs (95.7%) were deemed capable; 44 AD patients (68.8%) and 3 HCs (4.3%) incapable of consent. Age, education, and severity of cognitive deficits were associated with incapable status; there were no significant associations with severity of neuropsychiatric symptoms or protocol risk level.
conclusionsFindings highlight the importance of understanding of capacity and its assessment among people with AD, rather than treating AD diagnosis as synonymous with impaired capacity. As novel treatments move from bench to bedside, methods of assessing and addressing capacity impairment must similarly advance. CLINICAL IMPLICATIONS: In assessing research consent capacity, use structured assessments with population specific cut scores interpreted in the context of the person's background including education, culture, and language. Individuals should be encouraged to execute research proxy documents when able.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.