ArticleCancer prevention research (Philadelphia, Pa.)2017
Metformin Accumulation Correlates with Organic Cation Transporter 2 Protein Expression and Predicts Mammary Tumor Regression
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Article in Cancer prevention research (Philadelphia, Pa.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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Who cites it
26 citing papers in PubMed.
- Translating Metabolic Interventions into Breast Cancer Therapy: A Comprehensive Review.Life (Basel, Switzerland) · 2025Review
- Metformin and Breast Cancer: Current Findings and Future Perspectives from Preclinical and Clinical Studies.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Enhancement of targeted therapy in combination with metformin on human breast cancer cell lines.Cell communication and signaling : CCS · 2024Article
- Mechanisms of Regulation of the Expression of miRNAs and lncRNAs by Metformin in Ovarian Cancer.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Triple Therapy with Metformin, Ketogenic Diet, and Metronomic Cyclophosphamide Reduced Tumor Growth in MYCN-Amplified Neuroblastoma Xenografts.Metabolites · 2023Article
- Article
- Anticancer effects of metformin in experimental animal models of different types of cancer: a systematic review and meta-analysis.Laboratory animal research · 2022Article
- Divergent Metabolic Effects of Metformin Merge to Enhance Eicosapentaenoic Acid Metabolism and Inhibit Ovarian Cancer In Vivo.Cancers · 2022Article
- RETRACTED: Metformin and Breast Cancer: Where Are We Now?International journal of molecular sciences · 2022Review
- Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells.International journal of molecular sciences · 2021Article
- A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan.Frontiers in endocrinology · 2021Review
- Counteracting Chemoresistance with Metformin in Breast Cancers: Targeting Cancer Stem Cells.Cancers · 2020Review
- Compensatory eating behaviors in male and female rats in response to exercise training.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Effective Cellular Transport ofInternational journal of molecular sciences · 2020Article
- Metformin: The Answer to Cancer in a Flower? Current Knowledge and Future Prospects of Metformin as an Anti-Cancer Agent in Breast Cancer.Biomolecules · 2019Review
- Article
- Metformin and Breast Cancer: Molecular Targets.Journal of mammary gland biology and neoplasia · 2019Review
- Diabetes, obesity, and subsequent risk of postmenopausal breast cancer among white and black women in the Southern Community Cohort Study.Cancer causes & control : CCC · 2019Article
- Metformin as an adjuvant in breast cancer treatment.SAGE open medicine · 2019Review
- Insulin-like growth factor-1, metabolic abnormalities, and pathological complete remission rate in HER2-positive breast cancer patients receiving neoadjuvant therapy.OncoTargets and therapy · 2019Article
Corrections and comments
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Authors and funding
11 authors.
L Allyson CheckleyDivision of Endocrinology, Metabolism and Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado.
Michael C RudolphDivision of Endocrinology, Metabolism and Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado.
Elizabeth A WellbergDepartment of Pathology, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado.
Erin D GilesDepartment of Nutrition and Food Science, Texas A&M University, College Station, Texas.
Reema S Wahdan-AlaswadDepartment of Pathology, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado.
Julie A HouckDivision of Endocrinology, Metabolism and Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado.
Susan M EdgertonDepartment of Pathology, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado.
Ann D ThorDepartment of Pathology, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado.
Pepper SchedinDepartment of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon.
Steven M AndersonDepartment of Pathology, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado.
Paul S MacLeanDivision of Endocrinology, Metabolism and Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado. paul.maclean@ucdenver.edu.
Funding
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0MColorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0MPILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6MThe functional role of microRNAs in the normal mammary glandP01HD038129 · NICHD · UNIVERSITY OF COLORADO DENVER · PI ANDERSON, STEVEN M · 2000 to 2015
$15.2MUCHSC: Building Interdisciplinary Research Careers in Women's HealthK12HD057022 · NICHD · UNIVERSITY OF COLORADO DENVER · PI REGENSTEINER, JUDITH G., SANTORO, NANETTE F. · 2007 to 2023
$8.5MTraining Program in Perinatal Biology and MedicineT32HD007186 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Paul Joseph Rozance · 1985 to 2026
$6.5MSex Hormones Differentially Regulate Production of Distinct Adipocyte PopulationP50HD073063 · NICHD · UNIVERSITY OF COLORADO DENVER · PI KOHRT, WENDY M · 2012 to 2017
$5.7MA Narrowed Window for Targeting Metabolic Flexibility in Breast Cancer PreventionR01CA164166 · NCI · UNIVERSITY OF COLORADO DENVER · PI MACLEAN, PAUL S., SCHEDIN, PEPPER J · 2013 to 2017
$1.6MObesity associated inflammation and postmenopausal breast cancer.R00CA169430 · NCI · TEXAS A&M AGRILIFE RESEARCH · PI GILES, ERIN · 2016 to 2018
$722kObesity associated inflammation and postmenopausal breast cancer.K99CA169430 · NCI · UNIVERSITY OF COLORADO DENVER · PI GILES, ERIN · 2013 to 2014
$218kNCATS NIH HHS UL1 TR001082NCI NIH HHS K99 CA169430NCI NIH HHS P30 CA046934NCI NIH HHS R00 CA169430NCI NIH HHS R01 CA164166NICHD NIH HHS K12 HD057022NICHD NIH HHS P01 HD038129NICHD NIH HHS P50 HD073063NICHD NIH HHS T32 HD007186NIDDK NIH HHS P30 DK048520
Abstract
Several epidemiologic studies have associated metformin treatment with a reduction in breast cancer incidence in prediabetic and type II diabetic populations. Uncertainty exists regarding which patient populations and/or tumor subtypes will benefit from metformin treatment, and most preclinical
Indexed as
AnimalsAntineoplastic AgentsCell ProliferationFemaleHypoglycemic AgentsMammary Neoplasms, ExperimentalMetforminOrganic Cation Transporter 2Organic Cation Transport ProteinsRatsRats, WistarAntineoplastic AgentsHypoglycemic AgentsMetforminOrganic Cation Transporter 2Organic Cation Transport ProteinsSlc22a2 protein, rat
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.