Evidence map›Paper›PMID 28154138›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

pK

Natalia Grytsyk, Junichi Sugihara, H Ronald Kaback, Petra Hellwig

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Allosteric effects of the coupling cation in melibiose transporter MelB.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Transcendent Aspects of Proton Channels.Annual review of physiology · 2024
    Review
  5. Review
  6. Review
  7. AspThe Journal of biological chemistry · 2020
    Article
  8. Article
  9. Article
  10. The proton electrochemical gradient induces a kinetic asymmetry in the symport cycle of LacY.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. It takes two to tango: The dance of the permease.The Journal of general physiology · 2019
    Review
  12. Arg302 governs the pKProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  13. Article
  14. Engineered occluded apo-intermediate of LacY.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  15. MgThe Journal of biological chemistry · 2018
    Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Natalia GrytsykLaboratoire de Bioélectrochimie et Spectroscopie, UMR 7140, Chimie de la Matière Complexe, Université de Strasbourg CNRS, 67081 Strasbourg, France.
Junichi SugiharaDepartment of Physiology, University of California, Los Angeles, CA 90095-7327.
H Ronald KabackDepartment of Physiology, University of California, Los Angeles, CA 90095-7327; rkaback@mednet.ucla.edu hellwig@unistra.fr.
Petra HellwigLaboratoire de Bioélectrochimie et Spectroscopie, UMR 7140, Chimie de la Matière Complexe, Université de Strasbourg CNRS, 67081 Strasbourg, France; rkaback@mednet.ucla.edu hellwig@unistra.fr.
Université de Strasbourg · FRUniversity of California, Los Angeles · US

Funding

NEW APPROACHES TO MEMBRANE PROTEIN STRUCTURESR01DK051131 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KABACK, HOWARD RONALD · 1996 to 2014
$5.2M
Dynamics of the Lactose Permease of Escherichia ColiR01GM120043 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WRIGHT, ERNEST M · 2016 to 2019
$1.8M
Dynamics of the Lactose Permease of Escherichia ColiR56DK051131 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KABACK, HOWARD RONALD · 2015 to 2015
$154k
NIDDK NIH HHS R01 DK051131NIDDK NIH HHS R56 DK051131NIGMS NIH HHS R01 GM120043
6 · The paper itself

Abstract

Lactose permease (LacY), a paradigm for the largest family of membrane transport proteins, catalyzes the coupled translocation of a galactoside and a H

Indexed as

Amino Acid SubstitutionEnzymes, ImmobilizedEscherichia coliEscherichia coli ProteinsGalactoseGlutamic AcidHydrogen-Ion ConcentrationModels, MolecularMonosaccharide Transport ProteinsMutation, MissenseNitrophenylgalactosidesp21-Activated KinasesPoint MutationProtein BindingProtein ConformationProtonsEnzymes, ImmobilizedEscherichia coli ProteinsGalactoseGlutamic AcidLacY protein, E coliMonosaccharide Transport ProteinsNitrophenylgalactosidesp21-Activated KinasesProtonsRecombinant ProteinsSymporterslactose permeasemembrane proteinsprotonationsurface-enhanced infrared spectroscopytransport

Identifiers

PMID28154138
PMCPMC5320973
OpenAlexW2583695921

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.