Evidence map›Paper›PMID 28154085›Full record

ArticleHaematologica2017

Loss of Forkhead box M1 promotes erythropoiesis through increased proliferation of erythroid progenitors.

Minyoung Youn, Nan Wang, Corinne LaVasseur, Elena Bibikova, Sharon Kam, Bertil Glader, Kathleen M Sakamoto, Anupama Narla

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Minyoung YounDepartment of Pediatrics, Stanford University School of Medicine, CA, USA.
Nan WangDepartment of Pediatrics, Stanford University School of Medicine, CA, USA.
Corinne LaVasseurDepartment of Pediatrics, Stanford University School of Medicine, CA, USA.
Elena BibikovaDepartment of Pediatrics, Stanford University School of Medicine, CA, USA.
Sharon KamDepartment of Pediatrics, Stanford University School of Medicine, CA, USA.
Bertil GladerDepartment of Pediatrics, Stanford University School of Medicine, CA, USA.
Kathleen M SakamotoDepartment of Pediatrics, Stanford University School of Medicine, CA, USA.
Anupama NarlaDepartment of Pediatrics, Stanford University School of Medicine, CA, USA anunarla@stanford.edu.
Stanford University · US

Funding

TUMOR CELL SURFACES AND CHROMOSOMEST32CA009056 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gay M Crooks, David A. Nathanson · 1985 to 2026
$10.5M
Training in Pediatric Nonmalignant Hematology and Stem Cell BiologyT32DK098132 · NIDDK · STANFORD UNIVERSITY · PI SAKAMOTO, KATHLEEN M · 2014 to 2022
$1.9M
Molecular Pathogenesis of Diamond Blackfan AnemiaR01HL097561 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIN, SHUO, SAKAMOTO, KATHLEEN M · 2010 to 2013
$1.7M
Signaling Pathways in MDSR01DK107286 · NIDDK · STANFORD UNIVERSITY · PI SAKAMOTO, KATHLEEN M · 2016 to 2019
$1.4M
Novel therapeutic targets for Diamond Blackfan anemia and other ribosomopathiesK08DK090145 · NIDDK · STANFORD UNIVERSITY · PI NARLA, ANUPAMA · 2012 to 2016
$773k
NCI NIH HHS T32 CA009056NHLBI NIH HHS R01 HL097561NIDDK NIH HHS K08 DK090145NIDDK NIH HHS R01 DK107286NIDDK NIH HHS T32 DK098132
6 · The paper itself

Abstract

Forkhead box M1 (FOXM1) belongs to the forkhead/winged-helix family of transcription factors and regulates a network of proliferation-associated genes. Its abnormal upregulation has been shown to be a key driver of cancer progression and an initiating factor in oncogenesis. FOXM1 is also highly expressed in stem/progenitor cells and inhibits their differentiation, suggesting that FOXM1 plays a role in the maintenance of multipotency. However, the exact molecular mechanisms by which FOXM1 regulates human stem/progenitor cells are still uncharacterized. To understand the role of FOXM1 in normal hematopoiesis, human cord blood CD34

Indexed as

Antigens, CD34Cell DifferentiationCell ProliferationCells, CulturedCheckpoint Kinase 2Erythroid CellsErythroid Precursor CellsErythropoiesisFetal BloodForkhead Box Protein M1Gene Expression ProfilingHEK293 CellsHumansK562 CellsPhosphorylationPyridinesAntigens, CD34Checkpoint Kinase 2CHEK2 protein, humanFDI-6 compoundForkhead Box Protein M1FOXM1 protein, humanPyridinesThiophenes

Identifiers

PMID28154085
PMCPMC5477601
OpenAlexW2584356990

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.