ArticleScience (New York, N.Y.)2017
Formation of α-chiral centers by asymmetric β-C(sp3)-H arylation, alkenylation, and alkynylation.
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 211 citations in OpenAlex.
- Ligand-Enabled Stereoselective Coupling of Methylene C(spAngewandte Chemie (International ed. in English) · 2026Article
- Pd(II)-Catalyzed Strategies for the β-Arylation of α-Amino Acids: An Overview.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Intermolecular Enantioselective Nickel-Catalyzed Arylation of Un-Activated C(spAngewandte Chemie (International ed. in English) · 2026Article
- Enantioselective C-H Activation for the Construction of Chiral Tertiary Fluorides via Migrative Carbofluorination.Journal of the American Chemical Society · 2026Article
- Conformation-driven C3-C(Nature catalysis · 2026Article
- Transition-Metal-Catalyzed C(spTopics in current chemistry (Cham) · 2025Review
- Enantioselective β-C(spJournal of the American Chemical Society · 2025Article
- Synthesis of Chiral Saturated Heterocycles Bearing Quaternary Centers via Enantioselective β-C(spJournal of the American Chemical Society · 2025Article
- Article
- Synthesis of Chiral Carbocycles via Enantioselective β,γ-Dehydrogenation.Nature synthesis · 2024Article
- Article
- One-Step Synthesis of Chiral 9,10-Dihydrophenanthrenes via Ligand-Enabled Enantioselective Cascade β,γ-Diarylation of Acids.Angewandte Chemie (International ed. in English) · 2024Article
- Vitamin BRSC advances · 2024Article
- Enantioselective remote methylene C-H (hetero)arylation of cycloalkane carboxylic acids.Science (New York, N.Y.) · 2024Article
- Palladium (II)-Catalyzed C-H Activation with Bifunctional Ligands: From Curiosity to Industrialization.Angewandte Chemie (International ed. in English) · 2024Review
- Atroposelective hydroarylation of biaryl phosphines directed by phosphorus centres.Nature communications · 2023Article
- Rhodium-catalyzed enantioselective C-H alkynylation of sulfoxides in diverse patterns: desymmetrization, kinetic resolution, and parallel kinetic resolution.Chemical science · 2023Article
- Ligand-Enabled β-C(spAngewandte Chemie (International ed. in English) · 2022Article
- Palladium-Catalyzed Enantioselective β-C(spAccounts of chemical research · 2022Article
- Transition-Metal-Catalyzed, Coordination-Assisted Functionalization of Nonactivated C(spChemical reviews · 2021Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
The enzymatic β-C-H hydroxylation of the feedstock chemical isobutyric acid has enabled the asymmetric synthesis of a wide variety of polyketides. The analogous transition metal-catalyzed enantioselective β-C-H functionalization of isobutyric acid-derived substrates should provide a versatile method for constructing useful building blocks with enantioenriched α-chiral centers from this abundant C-4 skeleton. However, the desymmetrization of ubiquitous isopropyl moieties by organometallic catalysts has remained an unanswered challenge. Herein, we report the design of chiral mono-protected aminomethyl oxazoline ligands that enable desymmetrization of isopropyl groups via palladium insertion into the C(sp
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.