ArticleThe Journal of general physiology2017
Mechanisms creating transient and sustained photoresponses in mammalian retinal ganglion cells.
Article in The Journal of general physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Bipolar cell networks underlying steady-state intensity encoding in intrinsically photosensitive retinal ganglion cells.iScience · 2026Article
- Article
- Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array.iScience · 2024Article
- Adeno-associated virus (AAV)-mediated Cre recombinase expression in melanopsin ganglion cells without leaky expression in rod/cone photoreceptors.Journal of neuroscience methods · 2023Article
- Evaluating the Talbot-Plateau law.Frontiers in neuroscience · 2023Review
- Retinal Glutamate Neurotransmission: From Physiology to Pathophysiological Mechanisms of Retinal Ganglion Cell Degeneration.Life (Basel, Switzerland) · 2022Review
- Review
- An uncommon neuronal class conveys visual signals from rods and cones to retinal ganglion cells.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Structure and function of the gap junctional network of photoreceptive ganglion cells.Visual neuroscience · 2021Article
- Amacrine Cells Forming Gap Junctions With Intrinsically Photosensitive Retinal Ganglion Cells: ipRGC Types, Neuromodulator Contents, and Connexin Isoform.Investigative ophthalmology & visual science · 2021Article
- Effects of tACS-Like Electrical Stimulation on On-Center Retinal Ganglion Cells: Part I.Eye and brain · 2021Article
- Circadian Photoentrainment in Mice and Humans.Biology · 2020Review
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- The Roles of Rods, Cones, and Melanopsin in Photoresponses of M4 Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) and Optokinetic Visual Behavior.Frontiers in cellular neuroscience · 2018Article
- Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina.Scientific reports · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Retinal neurons use sustained and transient light responses to encode visual stimuli of different frequency ranges, but the underlying mechanisms remain poorly understood. In particular, although earlier studies in retinal ganglion cells (RGCs) proposed seven potential mechanisms, all seven have since been disputed, and it remains unknown whether different RGC types use different mechanisms or how many mechanisms are used by each type. Here, we conduct a comprehensive survey in mice and rats of 12 candidate mechanisms that could conceivably produce tonic rod/cone-driven ON responses in intrinsically photosensitive RGCs (ipRGCs) and transient ON responses in three types of direction-selective RGCs (TRHR+, Hoxd10+ ON, and Hoxd10+ ON-OFF cells). We find that the tonic kinetics of ipRGCs arises from their substantially above-threshold resting potentials, input from sustained ON bipolar cells, absence of amacrine cell inhibition of presynaptic ON bipolar cells, and mGluR7-mediated maintenance of light-evoked glutamatergic input. All three types of direction-selective RGCs receive input from transient ON bipolar cells, and each type uses additional strategies to promote photoresponse transience: presynaptic inhibition and dopaminergic modulation for TRHR+ cells, center/surround antagonism and relatively negative resting potentials for Hoxd10+ ON cells, and presynaptic inhibition for Hoxd10+ ON-OFF cells. We find that the sustained nature of ipRGCs' rod/cone-driven responses depends neither on melanopsin nor on
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