Evidence map›Paper›PMID 28153854›Full record

ArticleMolecular pharmacology2017

Sequence-Specific Regulation of Endocytic Lifetimes Modulates Arrestin-Mediated Signaling at the

Zara Y Weinberg, Amanda S Zajac, Tiffany Phan, Daniel J Shiwarski, Manojkumar A Puthenveedu

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Opioid Pharmacology under the Microscope.Molecular pharmacology · 2020
    Review
  9. Article
  10. Article
  11. Spatial encoding of GPCR signaling in the nervous system.Current opinion in cell biology · 2019
    Review
  12. Article
  13. Review
  14. Article
  15. Subcellular Organization of GPCR Signaling.Trends in pharmacological sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zara Y WeinbergDepartment of Biological Sciences, Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania.
Amanda S ZajacDepartment of Biological Sciences, Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania.
Tiffany PhanDepartment of Biological Sciences, Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania.
Daniel J ShiwarskiDepartment of Biological Sciences, Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania.
Manojkumar A PuthenveeduDepartment of Biological Sciences, Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania map3@andrew.cmu.edu.
Center for the Neural Basis of Cognition · USCarnegie Mellon University · US

Funding

Predoctorial Training in Basic NeuroscienceT32NS007433 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MERINEY, STEPHEN D · 1998 to 2022
$8.0M
MECHANISMS ENSURING SEQUENCE-DEPENDENT GPCR RECYCLINGR01GM117425 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 2016 to 2020
$1.5M
Regulation of Clathrin-Coated Pits by the Mu-Opioid ReceptorR00DA024698 · NIDA · CARNEGIE-MELLON UNIVERSITY · PI PUTHENVEEDU, MANOJKUMAR A · 2009 to 2011
$735k
TRAFFICKING AND FUNCTION OF MU-OPIOD RECEPTOR GENETIC VARIANTSR21DA036086 · NIDA · CARNEGIE-MELLON UNIVERSITY · PI PUTHENVEEDU, MANOJKUMAR A · 2013 to 2014
$371k
Regulation of Clathrin-Coated Pits by the Mu-Opioid ReceptorK99DA024698 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PUTHENVEEDU, MANOJKUMAR A · 2008 to 2008
$74k
NIDA NIH HHS K99 DA024698NIDA NIH HHS R00 DA024698NIDA NIH HHS R21 DA036086NIGMS NIH HHS R01 GM117425NINDS NIH HHS T32 NS007433
6 · The paper itself

Abstract

Functional selectivity at the

Indexed as

EndocytosisSignal TransductionAmino Acid Sequencebeta-ArrestinsEnzyme ActivationExtracellular Signal-Regulated MAP KinasesHEK293 CellsHumansMAP Kinase Signaling SystemMorphineMutationOligopeptidesReceptors, Opioid, muTime Factorsbeta-Arrestinsendomorphin 2Extracellular Signal-Regulated MAP KinasesMorphineOligopeptidesReceptors, Opioid, mu

Identifiers

PMID28153854
PMCPMC5363713
OpenAlexW2585718662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.