Evidence map›Paper›PMID 28153671›Full record

ReviewChest2017

Insomnia and Risk of Cardiovascular Disease.

Sogol Javaheri, Susan Redline

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chest, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 340 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
340citing papers in PubMed, 13 pooled it
35.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05414864 phase4terminatednot on this mapstarted 2022, after this paper: background citation

Insomnia Prevalence and Treatment Impact on Systemic Hypertension

TypeinterventionalSponsorUniversity of Sao PauloRan2022 to 2022Enrolled5ConditionsInsomnia, HypertensionArmsRamelteon (RozeremR), sleep hygiene
NCT06149273 narecruitingnot on this mapstarted 2023, after this paper: background citation

Treatment of Insomnia in Primary Care Study

TypeinterventionalSponsorUniversity of TurkuRan2023 to 2029Enrolled250ConditionsInsomnia ChronicArmsSleep School, Treatment as usual
3 · Its place in the literature

Who cites it

340 citing papers in PubMed, 13 syntheses or guidelines pooled it, 677 citations in OpenAlex.

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  6. The effects of cognitive behavioral therapy for insomnia in patients with cardiovascular disease: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
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  8. Associations between insomnia and cardiovascular diseases: a meta-review and meta-analysis of observational and Mendelian randomization studies.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
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  14. Trial
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  20. Association Between Serum Trace Elements and Obstructive Sleep Apnea in Iranian Adults: Multiple-exposure Models.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2026
    Article

280 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sogol JavaheriDepartment of Medicine, Division of Sleep, Circadian Rhythm, and Neurobiology, Brigham and Women's Hospital, Boston, MA. Electronic address: sjavaheri@partners.org.
Susan RedlineDepartment of Medicine, Division of Sleep, Circadian Rhythm, and Neurobiology, Brigham and Women's Hospital, Boston, MA; Department of Medicine, Division of Sleep, Beth Israel Deaconess Medical Center, Boston, MA.
Beth Israel Deaconess Medical Center · USCircadian (United States) · US

Funding

TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5M
NHLBI NIH HHS T32 HL007901
6 · The paper itself

Abstract

Insomnia is the most prevalent sleep disorder in the United States and has high comorbidity with a number of cardiovascular diseases (CVDs). In the past decade, a number of observational studies have demonstrated an association between insomnia and incident cardiovascular disease (CVD) morbidity and mortality, including hypertension (HTN), coronary heart disease (CHD), and heart failure (HF). Despite some inconsistencies in the literature, likely due to variations in how insomnia is defined and measured, the existing data suggest that insomnia, especially when accompanied by short sleep duration, is associated with increased risk for HTN, CHD and recurrent acute coronary syndrome, and HF. Purported mechanisms likely relate to dysregulation of the hypothalamic-pituitary axis, increased sympathetic nervous system activity, and increased inflammation. This paper reviews the most recent studies of insomnia and CVD and the potential pathophysiological mechanisms underlying this relationship and highlights the need for randomized trials to further elucidate the nature of the relationship between insomnia and CVD.

Indexed as

Autonomic Nervous System DiseasesCardiovascular DiseasesCoronary DiseaseC-Reactive ProteinHeart FailureHumansHypertensionHypothalamo-Hypophyseal SystemObservational Studies as TopicPituitary-Adrenal SystemRisk FactorsSleep Initiation and Maintenance DisordersC-Reactive Proteincardiovascular diseaseinsomniasleep medicine

Identifiers

PMID28153671
PMCPMC5577359
OpenAlexW2582214045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.