ArticleAmerican journal of obstetrics and gynecology2017
First trimester alcohol exposure alters placental perfusion and fetal oxygen availability affecting fetal growth and development in a non-human primate model.
Article in American journal of obstetrics and gynecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 71 citations in OpenAlex.
- Vitamin C supplementation improves placental function and alters placental gene expression in smokers.Scientific reports · 2024Trial
- Prenatal alcohol exposure affects placental degradation-a retrospective fetal MRI study.European radiology · 2026Article
- Decoding neurodevelopment risks of exposures to intoxication, infection, and trauma during pregnancy.Pregnancy (Hoboken, N.J.) · 2026Review
- Association of maternal alcohol consumption with frequent nocturnal enuresis in offspring.European child & adolescent psychiatry · 2026Article
- Early Peri-conceptional Alcohol Exposure before Implantation Disrupts Placental Development across Gestation.Research square · 2026Article
- Current approaches and advances in placental toxicology.Trends in endocrinology and metabolism: TEM · 2026Review
- Non-human primates as a translational model for the study of male reproductive health.Nature reviews. Urology · 2025Review
- Substance use and use disorders during pregnancy and the postpartum period.American journal of obstetrics and gynecology · 2025Review
- Prenatal alcohol exposure is associated with altered feto-placental blood flow and sex-specific placental changes.JCI insight · 2025Article
- Investigating the Impact of Chronical Prenatal Alcohol Exposure on Fetal Vascular Development Across Pregnancy Stages Using Photoacoustic Tomography.Journal of biophotonics · 2025Article
- Prenatal environmental exposures and brain development: studies with baboons and other nonhuman primates.Advances in drug and alcohol research · 2025Review
- Nonconceptus Mechanisms of Prenatal Alcohol Exposure That Disrupt Embryo-Fetal Development: An Integrative View.Alcohol research : current reviews · 2025Review
- Longitudinal intravital imaging of mouse placenta.Science advances · 2024Article
- Prenatal tobacco and alcohol exposure, white matter microstructure, and early language skills in toddlers from a South African birth cohort.Frontiers in integrative neuroscience · 2024Article
- The human placenta project: Funded studies, imaging technologies, and future directions.Placenta · 2023Review
- Associations between prenatal alcohol and tobacco exposure on Doppler flow velocity waveforms in pregnancy: a South African study.BMC pregnancy and childbirth · 2023Article
- Ultrasound evaluation of normal rhesus macaque fetal biometry and uteroplacental hemodynamics.American journal of primatology · 2023Article
- Impaired placental hemodynamics and function in a non-human primate model of gestational protein restriction.Scientific reports · 2023Article
- Vascular Contributions to the Neurobiological Effects of Prenatal Alcohol Exposure.Advances in drug and alcohol research · 2023Article
- Path analysis of the impact of prenatal alcohol on adult vascular function.Alcohol, clinical & experimental research · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrenatal alcohol exposure leads to impaired fetal growth, brain development, and stillbirth. Placental impairment likely contributes to these adverse outcomes, but the mechanisms and specific vasoactive effects of alcohol that links altered placental function to impaired fetal development remain areas of active research.
objectiveRecently, we developed magnetic resonance imaging techniques in nonhuman primates to characterize placental blood oxygenation through measurements of T STUDY
designTimed-pregnant Rhesus macaques (n=12) were divided into 2 groups: control (n=6) and ethanol exposed (n=6). Animals were trained to self-administer orally either 1.5 g/kg/d of a 4% ethanol solution (equivalent to 6 drinks/d) or an isocaloric control fluid from preconception until gestational day 60 (term is G168). All animals underwent Doppler ultrasound scanning followed by magnetic resonance imaging that consisted of T
resultsFetal weight and biparietal diameter were significantly smaller in ethanol-exposed animals compared with control animals at gestational day 110. By Doppler ultrasound scanning, placental volume blood flow was significantly lower (P=.04) at gestational day 110 in ethanol-exposed vs control animals. A significant reduction in placental blood flow was evident by dynamic contrast-enhanced magnetic resonance imaging. As we demonstrated recently, T
conclusionChronic first-trimester ethanol exposure significantly reduces placental perfusion and oxygen supply to the fetal vasculature later in pregnancy. These perturbations of placental function are associated with fetal growth impairments. However, differences between ethanol-exposed and control animals in placental function and fetal developmental outcomes were smaller at gestational day 135 than at gestational day 110. These findings are consistent with placental adaptation to early perturbations that allow for compensated placental function and maintenance of fetal growth.
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