Evidence map›Paper›PMID 28153641›Full record

ReviewThe lancet. Psychiatry2017

How do antidepressants work? New perspectives for refining future treatment approaches.

Catherine J Harmer, Ronald S Duman, Philip J Cowen

4 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The lancet. Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 251 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
251citing papers in PubMed, 18 pooled it
28.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03742557 phase3unknown statusnot on this mapstarted 2018, after this paper: background citation

Evaluation of Schemes of Administration of Intravenous Ketamine in Treatment-resistant Depression: Clinical-neuroimaging Correlation

TypeinterventionalSponsorNational Institute of Neurology and Neurosurgery, MexicoRan2018 to 2020Enrolled30ConditionsTreatment Resistant DepressionArmsKetamine 50 MG/ML Injectable Solution, 0.5 mg/kg IV
NCT03966859 nacompletednot on this mapstarted 2019, after this paper: background citation

The Effect of Seven-Day Atorvastatin Administration on Emotional Processing, Reward Processing, and Inflammation in Healthy Volunteers

TypeinterventionalSponsorUniversity of OxfordRan2019 to 2020Enrolled50ConditionsHealthyArmsAtorvastatin 20mg, Lactose placebo
NCT05963581 nacompletednot on this mapstarted 2023, after this paper: background citation

Investigating the Effects of Social Movement on Mood and Social and Emotional Functioning in Young People Experiencing Low Mood

TypeinterventionalSponsorUniversity of OxfordRan2023 to 2024Enrolled121ConditionsDepression, Low Mood, Depressive Disorder, Mood DisordersArmsSalsa Dancing
NCT06363487 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of Single-dose Semaglutide on Cognition and Energy in Healthy Volunteers

TypeinterventionalSponsorUniversity of OxfordRan2024 to 2024Enrolled70ConditionsCognitive ChangeArmsSemaglutide, 0.5 mg/mL, Placebo, 0.9% NaCl 1.5mL
3 · Its place in the literature

Who cites it

251 citing papers in PubMed, 18 syntheses or guidelines pooled it, 597 citations in OpenAlex.

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  4. Antidepressants for low back pain and spine-related leg pain.The Cochrane database of systematic reviews · 2025
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  12. Prevention of depression in adults with long-term physical conditions.The Cochrane database of systematic reviews · 2021
    Pooled it
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  14. Antidepressant treatment for postnatal depression.The Cochrane database of systematic reviews · 2021
    Pooled it
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  19. Trial
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191 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Catherine J HarmerUniversity Department of Psychiatry, University of Oxford, Oxford, UK. Electronic address: catherine.harmer@psych.ox.ac.uk.
Ronald S DumanDepartment of Psychiatry, Yale School of Medicine, Yale University, New Haven, CT, USA.
Philip J CowenUniversity Department of Psychiatry, University of Oxford, Oxford, UK.
University of Oxford · GBYale University · US

Funding

Synaptic mechanisms underlying the rapid antidepressant actions of scopolamineR01MH105910 · NIMH · YALE UNIVERSITY · PI PICCIOTTO, MARINA R · 2014 to 2018
$2.2M
Medical Research Council MR/K022202/1NIMH NIH HHS R01 MH105910
6 · The paper itself

Abstract

Most currently available antidepressants target monoamine neurotransmitter function. However, a purely neurotransmitter-based explanation for antidepressant drug action is challenged by the delayed clinical onset of most agents and the need to explain how neurochemical changes reverse the many different symptoms of depression. Novel approaches to understanding of antidepressant drug action include a focus on early changes in emotional and social processing and the role of neural plasticity. In this Review, we discuss the ways in which these two different theories reflect different or complementary approaches, and how they might be integrated to offer novel solutions for people with depression. We consider the predictions made by these mechanistic approaches for the stratification and development of new therapeutics for depression, and the next steps that need to be made to facilitate this translation of science to the clinic.

Indexed as

Antidepressive AgentsDepressionEmotionsHumansNeuronal PlasticitySocial BehaviorAntidepressive Agents

Identifiers

PMID28153641
PMCPMC5410405
OpenAlexW2579967741

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.