ArticleEnvironment international2017
Incorporating ToxCast and Tox21 datasets to rank biological activity of chemicals at Superfund sites in North Carolina.
Article in Environment international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Implementing in vitro bioactivity data to modernize priority setting of chemical inventories.ALTEX · 2022Article
- The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology.Chemical research in toxicology · 2021Review
- Evaluating consumer exposure to disinfecting chemicals against coronavirus disease 2019 (COVID-19) and associated health risks.Environment international · 2020Article
- Cadmium exposure andEnvironmental epigenetics · 2019Article
- Using Tox21 High-Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements.Applied in vitro toxicology · 2019Article
- Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure.Environmental health perspectives · 2018Article
- ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models.BMC bioinformatics · 2018Article
- The US Federal Tox21 Program: A strategic and operational plan for continued leadership.ALTEX · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe Superfund program of the Environmental Protection Agency (EPA) was established in 1980 to address public health concerns posed by toxic substances released into the environment in the United States. Forty-two of the 1328 hazardous waste sites that remain on the Superfund National Priority List are located in the state of North Carolina.
methodsWe set out to develop a database that contained information on both the prevalence and biological activity of chemicals present at Superfund sites in North Carolina. A chemical characterization tool, the Toxicological Priority Index (ToxPi), was used to rank the biological activity of these chemicals based on their predicted bioavailability, documented associations with biological pathways, and activity in in vitro assays of the ToxCast and Tox21 programs.
resultsThe ten most prevalent chemicals found at North Carolina Superfund sites were chromium, trichloroethene, lead, tetrachloroethene, arsenic, benzene, manganese, 1,2-dichloroethane, nickel, and barium. For all chemicals found at North Carolina Superfund sites, ToxPi analysis was used to rank their biological activity. Through this data integration, residual pesticides and organic solvents were identified to be some of the most highly-ranking predicted bioactive chemicals. This study provides a novel methodology for creating state or regional databases of biological activity of contaminants at Superfund sites.
conclusionsThese data represent a novel integrated profile of the most prevalent chemicals at North Carolina Superfund sites. This information, and the associated methodology, is useful to toxicologists, risk assessors, and the communities living in close proximity to these sites.
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