Evidence map›Paper›PMID 28153517›Full record

ReviewBiotechnology advances

Microfluidics for cryopreservation.

Gang Zhao, Jianping Fu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biotechnology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Article
  3. Cryopreservation of biological materials: applications and economic perspectives.In vitro cellular & developmental biology. Animal · 2026
    Review
  4. Hyaluronic Acid-Based Bioink for Anisotropic Neural Tissue Cryobioprinting.International journal of extreme manufacturing · 2026
    Article
  5. Article
  6. Microfluidic Platforms for Cryopreservation.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. A highly active mineral-based ice nucleating agent supportsJournal of the Royal Society, Interface · 2023
    Article
  16. Article
  17. Methods to Measure Water Permeability.Advances in experimental medicine and biology · 2023
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gang ZhaoCenter for Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China, Hefei 230027, Anhui, PR China. Electronic address: zhaog@ustc.edu.cn.
Jianping FuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, MI 48109, USA.

Funding

Microfluidic Functional Immunophenotyping of Pediatric Patients Following CardiopR01HL119542 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CORNELL, TIMOTHY T, FU, JIANPING · 2014 to 2017
$2.7M
NHLBI NIH HHS R01 HL119542
6 · The paper itself

Abstract

Cryopreservation has utility in clinical and scientific research but implementation is highly complex and includes labor-intensive cell-specific protocols for the addition/removal of cryoprotective agents and freeze-thaw cycles. Microfluidic platforms can revolutionize cryopreservation by providing new tools to manipulate and screen cells at micro/nano scales, which are presently difficult or impossible with conventional bulk approaches. This review describes applications of microfluidic tools in cell manipulation, cryoprotective agent exposure, programmed freezing/thawing, vitrification, and in situ assessment in cryopreservation, and discusses achievements and challenges, providing perspectives for future development.

Indexed as

CryopreservationMicrofluidic Analytical TechniquesAnimalsCryoprotective AgentsCytological TechniquesEquipment DesignFreezingHumansMiceOocytesVitrificationCryoprotective AgentsCryopreservationCryoprotective agent loading/unloadingFreezing/thawingMicrofluidicsVitrification

Identifiers

PMID28153517
PMCPMC6236673

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.