Evidence map›Paper›PMID 28153441›Full record

ArticleOphthalmology2017

Dietary Intakes of Eicosapentaenoic Acid and Docosahexaenoic Acid and Risk of Age-Related Macular Degeneration.

Juan Wu, Eunyoung Cho, Edward L Giovannucci, Bernard A Rosner, Srinivas M Sastry, Walter C Willett, Debra A Schaumberg

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 6 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 6 syntheses or guidelines pooled it, 70 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Juan WuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Electronic address: juan.wu@mail.harvard.edu.
Eunyoung ChoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Dermatology, the Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Epidemiology, Brown School of Public Health, Providence, Rhode Island.
Edward L GiovannucciDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Bernard A RosnerDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Srinivas M SastryBethesda Retina, Bethesda, Maryland.
Walter C WillettDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Debra A SchaumbergDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Global Medical Affairs, Ophthalmics, Shire, Lexington, Massachusetts; Center for Translational Medicine, John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah.
Brigham and Women's Hospital · USHarvard University · USBrown University · USTakeda (United States) · US

Funding

Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
VITAL-AMD: Prevention of AMD in the VITamin D and OmegA-3 TrialR01EY021900 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHASMAN, DANIEL IAN, CHRISTEN, WILLIAM G · 2012 to 2015
$3.1M
Genetic Epidemiology of Age-Related Macular DegenerationR01EY017362 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHAUMBERG, DEBRA A · 2007 to 2011
$2.9M
PROSPECTIVE STUDY OF RISK FACTORS FOR EYE DISEASER01EY009611 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E. · 1995 to 2004
$2.2M
Molecular Risk Factors for Age-Related MaculopathyR01EY013834 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHAUMBERG, DEBRA A · 2002 to 2004
$945k
NCI NIH HHS R01 CA049449NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NEI NIH HHS R01 EY009611NEI NIH HHS R01 EY013834NEI NIH HHS R01 EY017362NEI NIH HHS R01 EY021900
6 · The paper itself

Abstract

purposeTo evaluate the associations between intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and the intermediate and advanced stages of age-related macular degeneration (AMD).

designProspective cohort study.

participantsWe followed 75 889 women from the Nurses' Health Study and 38 961 men from the Health Professionals Follow-Up Study who were at least 50 years old, from 1984 to 2012 and 1986 to 2010, respectively. Cohort participants are mostly white (≥95%).

methodsWe assessed dietary intake by a validated food frequency questionnaire (FFQ) at baseline and every 4 years. We calculated cumulative average intakes of EPA and DHA from FFQs and also computed predicted erythrocyte and plasma scores directly from food intake using regression models. Cox proportional hazards models were used to compute the associations with AMD outcomes.

main outcome measuresWe confirmed 1589 incident intermediate and 1356 advanced AMD cases (primarily neovascular AMD) with a visual acuity of 20/30 or worse, owing primarily to AMD, by medical record review.

resultsFor intermediate AMD, the pooled hazard ratio (HR) between the 2 cohorts for DHA comparing the extreme quintiles of intake was 0.78 (95% confidence interval [CI], 0.66-0.92; P trend, 0.008) and for EPA + DHA was 0.83 (95% CI, 0.71-0.98; P trend, 0.03). The pooled HR for fatty fish, comparing ≥5 servings per week to almost never, was 0.61 (95% CI, 0.46-0.81; P trend, <0.001). For advanced AMD, the pooled HR for DHA was 1.01 (95% CI, 0.84-1.21; P trend, 0.75) and for fatty fish was 0.80 (95% CI, 0.59-1.08; P trend, 0.11). Secondary analyses using predicted erythrocyte and plasma scores of EPA and DHA yielded slightly stronger inverse associations for intermediate AMD and similar results for advanced AMD.

conclusionsHigher intakes of EPA and DHA may prevent or delay the occurrence of visually significant intermediate AMD. However, the totality of current evidence for EPA and DHA and advanced AMD is discordant, though there was no association with advanced AMD in the present study.

Indexed as

Dietary SupplementsVisual AcuityAdultAgedDisease ProgressionDocosahexaenoic AcidsDose-Response Relationship, DrugEicosapentaenoic AcidFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRisk FactorsTime FactorsDocosahexaenoic AcidsEicosapentaenoic Acid

Identifiers

PMID28153441
PMCPMC5401792
OpenAlexW2582689965

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.