Evidence map›Paper›PMID 28153054›Full record

ArticleAlzheimer's research & therapy2017

Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer's disease pathology modulates cognitive performance.

Domilė Tautvydaitė, Deepti Kukreja, Jean-Philippe Antonietti, Hugues Henry, Armin von Gunten, Julius Popp

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Domilė TautvydaitėDepartment of Psychiatry, Service of Old Age Psychiatry, Lausanne University Hospital (CHUV), Ch. de Mont-Paisible 16, CH-1011, Lausanne, Switzerland.
Deepti KukrejaDepartment of Psychiatry, Service of Old Age Psychiatry, Lausanne University Hospital (CHUV), Ch. de Mont-Paisible 16, CH-1011, Lausanne, Switzerland.
Jean-Philippe AntoniettiInstitute of Psychology, University of Lausanne, Lausanne, Switzerland.
Hugues HenryService of Biomedicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Armin von GuntenDepartment of Psychiatry, Service of Old Age Psychiatry, Lausanne University Hospital (CHUV), Ch. de Mont-Paisible 16, CH-1011, Lausanne, Switzerland.
Julius PoppDepartment of Psychiatry, Service of Old Age Psychiatry, Lausanne University Hospital (CHUV), Ch. de Mont-Paisible 16, CH-1011, Lausanne, Switzerland. julius.popp@chuv.ch.
University of Lausanne · CHUniversity Hospital of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDuring adulthood, personality characteristics may contribute to the individual capacity to compensate the impact of developing cerebral Alzheimer's disease (AD) pathology on cognitive impairment in later life. In this study we aimed to investigate whether and how premorbid personality traits interact with cerebrospinal fluid (CSF) markers of AD pathology to predict cognitive performance in subjects with mild cognitive impairment or mild AD dementia and in participants with normal cognition.

methodsOne hundred and ten subjects, of whom 66 were patients with mild cognitive impairment or mild AD dementia and 44 were healthy controls, had a comprehensive medical and neuropsychological examination as well as lumbar puncture to measure CSF biomarkers of AD pathology (amyloid beta

resultsIn hierarchical multivariate regression analyses, including age, gender, education, APOEε4 status and cognitive level, premorbid neuroticism, conscientiousness and agreeableness modulated the effect of CSF biomarkers on cognitive performance. Low premorbid openness independently predicted lower levels of cognitive functioning after controlling for biomarker concentrations.

conclusionOur findings suggest that specific premorbid personality traits are associated with cerebral AD pathology and modulate its impact on cognitive performance. Considering personality characteristics may help to appraise a person's cognitive reserve and the risk of cognitive decline in later life.

Indexed as

CognitionPersonalityAgedAlzheimer DiseaseApolipoprotein E4BiomarkersCognitive DysfunctionFemaleHumansMaleMultivariate AnalysisNeuropsychological TestsRegression AnalysisRetrospective StudiesSpinal PunctureApolipoprotein E4BiomarkersAlzheimer’s diseaseCerebrospinal fluid biomarkersCognitionMild cognitive impairmentPremorbid personality

Identifiers

PMID28153054
PMCPMC5290611
OpenAlexW2584427047

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.