Evidence map›Paper›PMID 28153031›Full record

SynthesisJournal of orthopaedic surgery and research2017

Combined use of intravenous and topical versus intravenous tranexamic acid in primary total knee and hip arthroplasty: a meta-analysis of randomised controlled trials.

Jun-Feng Li, Hang Li, Hui Zhao, Jun Wang, Shen Liu, Yang Song, Hong-Fen Wu

Registry-linked trialOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of orthopaedic surgery and research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03109652 (Serial Use of Intravenous and Oral Tranexamic Acid in Primary Total Knee Arthroplasty Patients), which is not on this map. Cited by 26 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 10 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03109652 phase4unknown statusnot on this map

Serial Use of Intravenous and Oral Tranexamic Acid in Primary Total Knee Arthroplasty Patients: A Randomized Controlled Study

TypeinterventionalSponsorSeoul National University HospitalRan2017 to 2019Enrolled144ConditionsKnee OsteoarthritisArmsTranexamic Acid
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 10 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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  19. The efficiency and safety of intravenous tranexamic acid administration in open reduction and internal fixation of pelvic and acetabular fractures.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jun-Feng LiJi Lin Agricultural University Hospital, Ji Lin, China.
Hang LiChest surgery, Cancer hospital of Ji Lin, Ji Lin, China.
Hui ZhaoChest surgery, Cancer hospital of Ji Lin, Ji Lin, China.
Jun WangIntegrated TCM & Western Medicine Department, Cancer hospital of Ji Lin, Ji Lin, China.
Shen LiuPharmacy Department, Cancer hospital of Ji Lin, Ji Lin, China.
Yang SongChest surgery, Cancer hospital of Ji Lin, Ji Lin, China.
Hong-Fen WuDepartment of Radiotherapy, Cancer hospital of Ji Lin, Changchun, Ji Lin, China. 844092278@qq.com.
Linzhou Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis meta-analysis aimed to evaluate the efficiency and safety of combined intravenous and topical methods of application versus single intravenous of tranexamic acid in primary total knee and hip arthroplasty.

methodsA systematic search was carried out in MEDLINE (from 1966 to 25 September 2016), PubMed (from 1966 to 25 September 2016), Embase (from 1980 to 25 September 2016), ScienceDirect (from 1985 to 25 September 2016) and the Cochrane Library. Only high-quality randomised controlled trials (RCT) were identified. Two authors independently performed data extraction and quality assessment of included studies. Meta-analysis was conducted using Review Manager 5.1 software.

resultsSix RCTs that included 687 patients met the inclusion criteria. The present meta-analysis indicated that there were significant differences in terms of total blood loss (MD = -193.59, 95% CI -338.06 to -49.13, P = 0.009), transfusion rate (RD = -0.07, 95% CI -0.12 to -0.03, P = 0.001), haemoglobin decline (MD = -0.51, 95% CI -0.83 to -0.18, P = 0.01) and length of stay (MD = -0.20, 95% CI -0.38 to -0.02, P = 0.03) between groups.

conclusionsCombined administration of tranexamic acid (TXA) in patients with total knee and hip arthroplasty was associated with significantly reduced total blood loss, transfusion requirements, postoperative haemoglobin decline and length of stay compared to single application alone but was not associated with prolonged operation time. Moreover, no adverse effects, such as superficial infection, deep vein thrombus (DVT) or pulmonary embolism (PE), were associated with TXA. We suggest that combined administration of TXA demonstrated excellent clinical efficacy and safety in patients with total knee and hip arthroplasty. More importantly, well-designed studies with larger sample size are needed to provide further reliable evidence for the combined use of TXA.

Indexed as

Administration, IntravenousAdministration, TopicalAntifibrinolytic AgentsArthroplasty, Replacement, HipArthroplasty, Replacement, KneeBlood Loss, SurgicalHemostasis, SurgicalHumansRandomized Controlled Trials as TopicTranexamic AcidAntifibrinolytic AgentsTranexamic AcidBlood lossMeta-analysisTotal hip replacementTotal knee and hip arthroplastyTotal knee replacementTranexamic acid

Identifiers

PMID28153031
PMCPMC5290625
OpenAlexW2584297706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.