ArticleBMC microbiology2017
Origins and global context of Brucella abortus in Italy.
Article in BMC microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- First report of the isolation, characterization, and genotyping of Brucella abortus biovar 9 in Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Evaluation of brucellosis eradication strategies in water buffalo in a key dairy production area of southern Italy.Frontiers in microbiology · 2026Article
- Bacteriological and molecular characterization ofOpen veterinary journal · 2025Article
- Molecular typing methods to characterizeVeterinary world · 2024Review
- Global phylogenomic diversity ofFrontiers in microbiology · 2023Article
- Article
- Evaluation of a Real-time PCR in Combination with a Cultivation Method for the Detection ofJournal of veterinary research · 2022Article
- Whole Genome Sequence Analysis ofMicroorganisms · 2021Article
- Bovine brucellosis - a comprehensive review.The veterinary quarterly · 2021Review
- Article
- Review
- Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis.PLoS neglected tropical diseases · 2020Article
- Investigation of Genetic Relatedness ofFrontiers in veterinary science · 2020Article
- Molecular characterization of Brucella species from Zimbabwe.PLoS neglected tropical diseases · 2019Article
- Characterization of circulating miRNA signature in water buffaloes (Bubalus bubalis) during Brucella abortus infection and evaluation as potential biomarkers for non-invasive diagnosis in vaginal fluid.Scientific reports · 2019Article
- A MALDI-TOF MS database with broad genus coverage for species-level identification of Brucella.PLoS neglected tropical diseases · 2018Article
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrucellosis is a common and chronic disease of cattle and other bovids that often causes reproductive disorders. Natural infection in cattle is caused by Brucella abortus and transmission typically occurs during abortions, calving, or nursing. Brucellosis is also a major zoonotic disease due to contamination of dairy products or contact with the tissues of infected animals. Brucellosis has been eradicated from most of the developed world in the last 40 years but persists in many regions-the disease remains prevalent in portions of Africa, the Middle East, Asia, and Central and South America, as well as in the Mediterranean basin. In Italy, B. abortus has persisted in southern regions in both cattle and water buffalo. Previous attempts at analyzing the phylogenetics of B. abortus in Italy have been challenging due to limited genetic variability and unresolved global population genetic structure of this pathogen.
resultsWe conducted genome-wide phylogenetic analyses on 11 representative strains of B. abortus from Italy, and compared these sequences to a worldwide collection of publically available genomes. Italian isolates belong to three clades that are basal to the main and global B. abortus lineage. Using six SNP-based assays designed to identify substructure within the Italian clades, we surveyed a collection of 261 isolates and found that one clade predominates throughout endemic districts in the country, while the other two clades are more geographically restricted to portions of southern Italy.
conclusionsAlthough related strains exist worldwide, B. abortus isolates from Italy are substantially different than those found in much of the rest of Europe and North America, and are more closely related to strains from the Middle East and Asia. Our assays targeting genetic substructure within Italy allowed us to identify the major lineages quickly and inexpensively, without having to generate whole genome sequences for a large isolate collection. These findings highlight the importance of genetic studies to assess the status and the history of pathogens.
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