ArticleDepression and anxiety2017
Age of onset and family history as indicators of polygenic risk for major depression.
Article in Depression and anxiety, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Genetics of age-at-onset in major depression.Translational psychiatry · 2022Pooled it
- Association between premenstrual syndrome and postnatal depression in women with recurrent major depressive disorder.Psychiatry research · 2026Article
- Depression genetics through the lens of age at onset.Nature genetics · 2025Article
- The genetics of severe depression.Molecular psychiatry · 2025Review
- Familial risk for depressive and anxiety disorders: associations with genetic, clinical, and psychosocial vulnerabilities.Psychological medicine · 2022Article
- Family Genetic Risk Scores and the Genetic Architecture of Major Affective and Psychotic Disorders in a Swedish National Sample.JAMA psychiatry · 2021Article
- Update on the neurodevelopmental theory of depression: is there any 'unconscious code'?Pharmacological reports : PR · 2021Review
- Inflammatory versus Anti-inflammatory Profiles in Major Depressive Disorders-The Role of IL-17, IL-21, IL-23, IL-35 and Foxp3.Journal of personalized medicine · 2021Article
- Electroacupuncture Ameliorates Depression-Like Behaviour in Rats by Enhancing Synaptic Plasticity via the GluN2B/CaMKII/CREB Signalling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Electroacupuncture Relieves LPS-Induced Depression-Like Behaviour in Rats Through IDO-Mediated Tryptophan-Degrading Pathway.Neuropsychiatric disease and treatment · 2020Article
- Immune to happiness - inflammatory process indicators and depressive personality traits.Archives of medical science : AMS · 2020Article
- Robust symptom networks in recurrent major depression across different levels of genetic and environmental risk.Journal of affective disorders · 2018Article
- Genetics Factors in Major Depression Disease.Frontiers in psychiatry · 2018Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe extent to which earlier age of onset (AO) is a reflection of increased genetic risk for major depression (MD) is still unknown. Previous biometrical research has provided mixed empirical evidence for the genetic overlap of AO with MD. If AO is demonstrated to be relevant to molecular polygenic risk for MD, incorporation of AO as a phenotype could enhance future genetic studies.
methodsThis research estimated the SNP-based heritability of AO in the China, Oxford and VCU Experimental Research on Genetic Epidemiology (CONVERGE) case-control sample (N = 9,854; MD case, n = 4,927). Common single nucleotide polymorphism heritability of MD was also examined across both high and low median-split AO groups, and best linear unbiased predictor (BLUP) scores of polygenic risk, in split-halves, were used to predict AO. Distributions of genetic risk across early and late AO were compared, and presence of self-reported family history (FH) of MD was also examined as a predictor of AO.
resultsAO was not significantly heritable and polygenic risk derived from the aggregated effects of common genetic variants did not significantly predict AO in any analysis. AO was modestly but significantly lower in cases with a first-degree genetic FH of MD.
conclusionsFindings indicate that AO is associated with greater self-reported genetic risk for MD in cases, yet not associated with common variant polygenic risk for MD. Future studies of early MD may benefit more from the examination of important moderating variables such as early life events.
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