ArticleBritish journal of cancer2017
Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans.
Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- The preventive and carcinogenic effect of metals on cancer: a systematic review.BMC public health · 2024Pooled it
- Circulating Copper and Liver Cancer.Biological trace element research · 2023Pooled it
- Adjuvant therapy with zinc supplementation; anti-inflammatory and anti-oxidative role in multiple myeloma patients receiving autologous hematopoietic stem cell transplantation: a randomized controlled clinical trial.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Trial
- Relation of Serum Copper Status to Survival in COVID-19.Nutrients · 2021Trial
- Differences in Tissue Copper and Zinc Content Between Normal Livers and Those with Cirrhosis with or Without Hepatocellular Carcinoma.International journal of molecular sciences · 2025Article
- Review Article on Molecular Basis of Zinc and Copper Interactions in Cancer Physiology.Biological trace element research · 2025Review
- THE PLASMA CONCENTRATIONS OF ESSENTIAL TRACE ELEMENTS IN WOMEN WITH CANCER OF BREAST- OR CERVIX.Annals of Ibadan postgraduate medicine · 2024Article
- Antioxidant Properties of Zinc and Copper-Blood Zinc-to Copper-Ratio as a Marker of Cancer Risk BRCA1 Mutation Carriers.Antioxidants (Basel, Switzerland) · 2024Article
- Zinc and Its Antioxidant Properties: The Potential Use of Blood Zinc Levels as a Marker of Cancer Risk in BRCA1 Mutation Carriers.Antioxidants (Basel, Switzerland) · 2024Article
- Current Trends on the Involvement of Zinc, Copper, and Selenium in the Process of Hepatocarcinogenesis.Nutrients · 2024Review
- Exposure to PMJournal of epidemiology · 2024Article
- Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets.Signal transduction and targeted therapy · 2024Review
- Copper in Cancer: from transition metal to potential target.Human cell · 2024Review
- Connection between nutrition and oncology in dogs and cats: perspectives, evidence, and implications-a comprehensive review.Frontiers in veterinary science · 2024Review
- Bioinformatics prediction and experimental verification identify cuproptosis-related lncRNA as prognosis biomarkers of hepatocellular carcinoma.Biochemistry and biophysics reports · 2023Article
- Effect of Polyphenols and Zinc Co-Supplementation on the Development of Neoplasms in Rats with Breast Cancer.Foods (Basel, Switzerland) · 2023Article
- Copper metabolism and hepatocellular carcinoma: current insights.Frontiers in oncology · 2023Review
- Copper and cuproptosis-related genes in hepatocellular carcinoma: therapeutic biomarkers targeting tumor immune microenvironment and immune checkpoints.Frontiers in immunology · 2023Article
- Association between pre-diagnostic dietary copper, zinc, and copper-to-zinc ratio and severity of ovarian cancer.Frontiers in nutrition · 2022Article
- Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study.Nutrients · 2021Article
Corrections and comments
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Authors and funding
40 authors at 20 institutions in 15 countries.
Funding
Abstract
backgroundCopper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers.
methodsA nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n=106, IHDB n=34, GBTC n=96) and their matched controls (1:1). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk.
resultsFor HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR=0.36; 95% CI: 0.13-0.98, P
conclusionsZinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings.
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Registered trials
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