ReviewDementia and geriatric cognitive disorders2017
Association between Various Brain Pathologies and Gait Disturbance.
Review in Dementia and geriatric cognitive disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Neural Mechanisms of Motor Dysfunction in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review.Journal of Alzheimer's disease reports · 2022Pooled it
- Fall prevention in community-dwelling adults with mild to moderate cognitive impairment: a systematic review and meta-analysis.BMC geriatrics · 2021Pooled it
- The effects of transcranial direct current stimulation on gait in patients with Parkinson's disease: a systematic review.Translational neurodegeneration · 2021Pooled it
- Intranasal insulin enhances resting-state functional connectivity in Type 2 Diabetes.PloS one · 2025Trial
- Dual-task walking and automaticity after Stroke: Insights from a secondary analysis and imaging sub-study of a randomised controlled trial.Clinical rehabilitation · 2021Trial
- Comment on: Neuropathological diagnoses and age-related differences in Finnish medico-legal autopsies of individuals aged 65 years and older.Forensic science, medicine, and pathology · 2026Article
- Gait Disturbances and Alzheimer's Disease Pathology: Unresolved Causal-Temporal Ambiguities and Methodological Considerations for the Proposed Mechanistic Framework.Geriatrics & gerontology international · 2026Article
- Overweight/obesity and gait abnormality: what role does the brain play in the relationship?International journal of obesity (2005) · 2026Article
- Associations of accelerometry-derived time in major activity intensities with cognitive outcomes: a compositional data analysis approach.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Association of gait, balance, and fall risk with dementia in Down syndrome: a systematic review of the literature.Dementia & neuropsychologia · 2026Review
- Classifying simulated gait impairments using privacy-preserving explainable artificial intelligence and mobile phone videos.PLOS digital health · 2025Article
- Association of plasma biomarkers of Alzheimer's pathology and neurodegeneration with gait performance in older adults.Communications medicine · 2025Article
- Gray matter loss relates to dual task gait in Lewy body disorders and aging.Journal of neurology · 2024Article
- The Effect of the Human Brainstem Myelination on Gait Speed in Normative Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Association of Motor Function With Cognitive Trajectories and Structural Brain Differences: A Community-Based Cohort Study.Neurology · 2023Article
- Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment.BMC geriatrics · 2023Article
- Predictive power of gait and gait-related cognitive measures in amnestic mild cognitive impairment: a machine learning analysis.Frontiers in human neuroscience · 2023Article
- Neural correlates of slower gait in middle-aged persons with childhood-onset type 1 diabetes mellitus: The impact of accelerated brain aging.Journal of diabetes and its complications · 2022Article
- The Biological Substrate of the Motoric Cognitive Risk Syndrome: A Pilot Study Using Amyloid-/Tau-PET and MR Imaging.Journal of Alzheimer's disease : JAD · 2022Article
- Aging-related Alzheimer's disease-like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus).American journal of primatology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundApproximately 30% of older adults have disrupted gait. It is associated with increased risk of cognitive decline, disability, dementia, and death. Additionally, most older adults present with 1 or more neuropathologies at autopsy. Recently, there has been an effort to investigate the association between subclinical neuropathology and gait. SUMMARY: We reviewed studies that investigated the association between gait and neuropathologies. Although all pathologies reviewed were associated with gait, grey matter atrophy was most consistently linked with poorer gait performance. Studies investigating the association between white matter and gait focused primarily on total white matter. Future research using more parsed regional analysis will provide more insight into this relationship. Evidence from studies investigating neuronal activity and gait suggests that gait disruption is associated with both under- and overactivation. Additional research is needed to delineate these conflicting results. Lastly, early evidence suggests that both amyloid and tau aggregation negatively impact multiple gait parameters, but additional studies are warranted. Overall, there was substantial methodological heterogeneity and a paucity of longitudinal studies. Key Messages: Longitudinal studies mapping changes in different types of neuropathology as they relate to changes in multiple gait parameters are needed to better understand trajectories of pathology and gait.
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Registered trials
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