Evidence map›Paper›PMID 28152505›Full record

SynthesisOncotarget2017

Mean cerebral blood volume is an effective diagnostic index of recurrent and radiation injury in glioma patients: A meta-analysis of diagnostic test.

Zhanzhan Li, Qin Zhou, Yanyan Li, Shipeng Yan, Jun Fu, Xinqiong Huang, Liangfang Shen

Abstract readMeta-Analysis
In one paragraph

Synthesis in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhanzhan LiDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
Qin ZhouDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
Yanyan LiOffice of Cancer Prevent and Control, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
Shipeng YanOffice of Cancer Prevent and Control, Hunan Provincial Tumor Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013 China.
Jun FuDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
Xinqiong HuangDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
Liangfang ShenDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted a meta-analysis to evaluate the diagnostic values of mean cerebral blood volume for recurrent and radiation injury in glioma patients. We performed systematic electronic searches for eligible study up to August 8, 2016. Bivariate mixed effects models were used to estimate the combined sensitivity, specificity, positive likelihood ratios, negative likelihood ratios, diagnostic odds ratios and their 95% confidence intervals (CIs). Fifteen studies with a total number of 576 participants were enrolled. The pooled sensitivity and specificity of diagnostic were 0.88 (95%CI: 0.82-0.92) and 0.85 (95%CI: 0.68-0.93). The pooled positive likelihood ratio is 5.73 (95%CI: 2.56-12.81), negative likelihood ratio is 0.15 (95%CI: 0.10-0.22), and the diagnostic odds ratio is 39.34 (95%CI:13.96-110.84). The summary receiver operator characteristic is 0.91 (95%CI: 0.88-0.93). However, the Deek's plot suggested publication bias may exist (t=2.30, P=0.039). Mean cerebral blood volume measurement methods seems to be very sensitive and highly specific to differentiate recurrent and radiation injury in glioma patients. The results should be interpreted with caution because of the potential bias.

Indexed as

Cerebral Blood VolumeChemoradiotherapyFemaleGliomaHumansMaleNeoplasm Recurrence, LocalRadiation InjuriesRadiotherapyRadiotherapy DosageROC Curveearly diagnosisgliomamean cerebral blood volumemeta-analysis

Identifiers

PMID28152505
PMCPMC5362512

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.